This application responds to RFA-DE-05-006 for a General Dental Practice-Based Research Network, and is an application to serve as the Coordinating Center (CC) for the Practice-Based Research Network (PBRN) in the RFA. In conjunction with the proposed Network Chair, we have formed the """"""""Dental PBRN"""""""" that includes dentists from six US states and Scandinavia. We have a unique opportunity to build upon a statewide dental PBRN in Alabama which already has one NIH-funded R01 clinical trial and one NIH-funded R21 study in progress;and experience from large cross-sectional and longitudinal dental practice-based studies in Florida, Minnesota, the Pacific Northwest, and Scandinavia. Our application is best viewed as a joint response from the CC and the Network Chair-both groups must work as a fully-integrated entity. The Dental PBRN's primary scientific aims are to: (1) accelerate development and conduct of clinical research;(2) perform relatively short-term studies to compare effectiveness of preventive and treatment methods;and (3) strengthen the knowledge base for clinical decision making. Secondary aims are to: (1) conduct anonymous chart reviews;(2) provide data on treatment trends;and (3) estimate prevalence of less-common conditions. The Dental PBRN organizational structure comprises dental practices, the Network Chair administrative structure, the CC, the Executive Committee, the Protocol Review Committee, the Data &Safety Monitoring Board, the Observational Studies Monitoring Board, and NIDCR staff. We will assist the Network Chair and the Executive Committee to select practitioners to participate in specific studies and will organize protocol development, training procedures and materials and conduct training sessions. We will also establish and operate appropriate quality assurance programs assessing and monitoring practitioner performance and other key operational activities. We will adapt appropriate technology for data collection, data management and study analytical and publication issues. We will establish Safety and Data Management Boards and Observational Study Monitoring Boards for safety and ethical overview and will operate the IRB approval process for study protocols. This will include the creation and maintenance of a database documenting the consent process and any layers contained there.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DE016746-06
Application #
7841899
Study Section
Special Emphasis Panel (ZDE1-RR (02))
Program Officer
Denucci, D J
Project Start
2005-04-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
6
Fiscal Year
2010
Total Cost
$1,385,599
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Riley 3rd, J L; Gilbert, G H; Ford, G W et al. (2017) Judgment of the Quality of Restorative Care as Predictors of Restoration Retreatment: Findings from the National Dental PBRN. JDR Clin Trans Res 2:151-157
Mitchell, Sonya T; Funkhouser, Ellen; Gordan, Valeria V et al. (2017) Satisfaction with dental care among patients who receive invasive or non-invasive treatment for non-cavitated early dental caries: findings from one region of the National Dental PBRN. BMC Oral Health 17:70
Gordan, V V (2017) How to Bridge Research Results to Everyday Clinical Care? Oper Dent 42:1-9
Nixdorf, Donald R; Law, Alan S; Lindquist, Kimberly et al. (2016) Frequency, impact, and predictors of persistent pain after root canal treatment: a national dental PBRN study. Pain 157:159-65
Yokoyama, Yoko; Kakudate, Naoki; Sumida, Futoshi et al. (2016) Evidence-practice gap for dental sealant application: results from a dental practice-based research network in Japan. Int Dent J 66:330-336
Pigg, Maria; Nixdorf, Donald R; Nguyen, Ruby H N et al. (2016) Validity of Preoperative Clinical Findings to Identify Dental Pulp Status: A National Dental Practice-Based Research Network Study. J Endod 42:935-42
Yokoyama, Yoko; Kakudate, Naoki; Sumida, Futoshi et al. (2016) Evidence-practice gap for in-office fluoride application in a dental practice-based research network. J Public Health Dent 76:91-7
Cutrona, Sarah L; Sadasivam, Rajani S; DeLaughter, Kathryn et al. (2016) Online tobacco websites and online communities-who uses them and do users quit smoking? The quit-primo and national dental practice-based research network Hi-Quit studies. Transl Behav Med 6:546-557
Heaven, Tim J; Gordan, Valeria V; Litaker, Mark S et al. (2015) Concordance between responses to questionnaire scenarios and actual treatment to repair or replace dental restorations in the National Dental PBRN. J Dent 43:1379-84
Riley 3rd, Joseph L; Gordan, Valeria V; Ajmo, Craig T et al. (2015) Dentists' use of caries risk assessment and individualized caries prevention for their adult patients: Findings from The Dental Practice-Based Research Network. Tex Dent J 132:18-29

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