Salivary gland malignancies represent only 1-2% of all head and neck malignancies in the United States. Their behavior can be quite variable, and treatment usually involves surgery and radiation therapy. Because not much is known about the molecular mechanisms of these unusual tumors, chemotherapy and other targeted therapies have not been shown to be effective. As part of this collaborative proposal, our aim is to evaluate the role of promoter methylation as a means of tumor suppressor gene silencing using new microarray technology. We intend to use the Illumina Human Methylation27 array which is able to sample the methylation status of over 14,000 genes. We can then validate the identified targets and go on to perform further mechanistic studies of their biologic relevance in these malignancies. Performing this comprehensive analysis will allow us to determine the effect of epigenetic silencing on the carcinogenesis of salivary gland cancers.

Public Health Relevance

The goal of this grant is to help identify the significance of methyaltion in salivary gland cancers with the hopes of providing either therapeutic targets or markers for disease that can be used for prognosis or screening.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DE019765-04S1
Application #
8535979
Study Section
Special Emphasis Panel (ZRG1-HOP-Y (50))
Program Officer
Atkinson, Jane C
Project Start
2009-09-20
Project End
2014-05-31
Budget Start
2012-09-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$505,600
Indirect Cost
$185,600
Name
University of Texas MD Anderson Cancer Center
Department
Pathology
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Mitani, Yoshitsugu; Liu, Bin; Rao, Pulivarthi H et al. (2016) Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clin Cancer Res 22:725-33
Xu, Li; Tang, Hongwei; El-Naggar, Adel K et al. (2015) Genetic variants in DNA double-strand break repair genes and risk of salivary gland carcinoma: a case-control study. PLoS One 10:e0128753
Wang, Zhiming; Ling, Shizhang; Rettig, Eleni et al. (2015) Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration. Oral Oncol 51:1120-5
Xu, Li; Tang, Hongwei; Chen, Diane W et al. (2015) Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes. Cancer 121:2367-74
Reitzel, Lorraine R; Nguyen, Nga; Li, Nan et al. (2014) Trends in thyroid cancer incidence in Texas from 1995 to 2008 by socioeconomic status and race/ethnicity. Thyroid 24:556-67
Mitani, Yoshitsugu; Rao, Pulivarthi H; Maity, Sankar N et al. (2014) Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications. Clin Cancer Res 20:6570-81
Bell, Diana; Hanna, Ehab Y; Miele, Lucio et al. (2014) Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma. Ann Diagn Pathol 18:10-3
Gao, Ruli; Cao, Chunxia; Zhang, Min et al. (2014) A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets. Oncotarget 5:12528-42
Zhou, Jane H; Hanna, Ehab Y; Roberts, Dianna et al. (2013) ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma. Head Neck 35:575-8
Ivanov, S V; Panaccione, A; Nonaka, D et al. (2013) Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. Br J Cancer 109:444-51

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