Salivary gland malignancies represent only 1-2% of all head and neck malignancies in the United States. Their behavior can be quite variable, and treatment usually involves surgery and radiation therapy. Because not much is known about the molecular mechanisms of these unusual tumors, chemotherapy and other targeted therapies have not been shown to be effective. As part of this collaborative proposal, our aim is to evaluate the role of promoter methylation as a means of tumor suppressor gene silencing using new microarray technology. We intend to use the Illumina Human Methylation27 array which is able to sample the methylation status of over 14,000 genes. We can then validate the identified targets and go on to perform further mechanistic studies of their biologic relevance in these malignancies. Performing this comprehensive analysis will allow us to determine the effect of epigenetic silencing on the carcinogenesis of salivary gland cancers.

Public Health Relevance

The goal of this grant is to help identify the significance of methyaltion in salivary gland cancers with the hopes of providing either therapeutic targets or markers for disease that can be used for prognosis or screening.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DE019765-05
Application #
8514402
Study Section
Special Emphasis Panel (ZRG1-HOP-Y (50))
Program Officer
Atkinson, Jane C
Project Start
2009-09-20
Project End
2014-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
5
Fiscal Year
2013
Total Cost
$1,216,640
Indirect Cost
$359,687
Name
University of Texas MD Anderson Cancer Center
Department
Pathology
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
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Mitani, Yoshitsugu; Rao, Pulivarthi H; Maity, Sankar N et al. (2014) Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications. Clin Cancer Res 20:6570-81
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Zhang, Fenghua; Xu, Li; Wei, Qingyi et al. (2013) Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma. Surgery 153:711-7
Zhang, Li; Mitani, Yoshitsugu; Caulin, Carlos et al. (2013) Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance. Am J Pathol 182:2048-57
Mitani, Yoshitsugu; Roberts, Dianna B; Fatani, Hanadi et al. (2013) MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. PLoS One 8:e66778
Stephens, Philip J; Davies, Helen R; Mitani, Yoshitsugu et al. (2013) Whole exome sequencing of adenoid cystic carcinoma. J Clin Invest 123:2965-8
Ivanov, S V; Panaccione, A; Nonaka, D et al. (2013) Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. Br J Cancer 109:444-51
Xu, Li; Doan, Phi C; Wei, Qingyi et al. (2012) Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma. Thyroid 22:35-43

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