The short average service life of current dental composite restorative systems and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting dental materials having novel monomers and polymers, reinforcing fillers, and adhesive components. The goal of this proposed research is to develop novel dental composite systems, for use in restorations, sealants, and other dental services that are superior in properties and endurance to currently used Bis-GMA/TEGDMA and urethane-dimethacrylate systems. We will design and produce new monomers and their polymers that are not susceptible to enzymatic or hydrolytic degradation, establish a self- healing technique to significantly extend the fatigue lif of these composites, and formulate smart antibacterial components which are activated in the oral environment only when needed. We propose three specific aims that target these three key developments.
In Specific Aim 1, we propose to improve durability by replacing the hydrolyzable ester groups, contained in current polymers and bonding agents, with hydrolytically stable ether groups in the corresponding polymers and bonding agents.
In Specific Aim 2, we will develop self-healing dental composites (SHDC) that will autonomously repair micro-cracks that are hard to detect and almost impossible to repair clinically. Autonomic self-healing will significantly improve the durability of these materials by preventing catastrophic failures caused by thermal and mechanical challenges encountered in the oral environment.
In Specific Aim 3, we propose to build a self-defense capability for the systems by incorporating nanoparticles functionalized with novel coupling agents that will release antimicrobial components only when exposed to bacterial attack or hydrolytic degradation. The integrity and durability of these novel systems wil be compared with Bis-GMA/TEGDMA based commercial systems under challenges like those that occur in the oral environment, including cariogenic biofilms, enzymatic degradations, thermal cycling fatigue and mechanical cycling fatigue. We expect that the novel materials, having features achieved by these three specific aims, will significantly surpass the performances of current Bis-GMA-TEGDMA-based commercial materials under these challenges. It is thus predictable that the new system will provide a significantly extended service life, at least by a factor of two. All of the features in the new system can be easily integrated into other restorative systems developed by the awardees of this U01-RFA, and can be used in composites and their dental adhesives. We plan to share our data and resources and collaborate with the awardees by way of all feasible procedure to achieve the goals of this program.
The proposed research is to develop novel dental composite restorative systems that are superior in properties and endurance to currently used Bis-GMA/TEGDMA systems, which are combinations of Bis- GMA-TEGDMA-based polymer, filler particles, and coupling agents to bind the polymer to the filler particles. We will design and produce new monomers and their polymers that are BPA-free and not susceptible to enzymatic or hydrolytic degradation, establish self-healing systems to significantly extend the fatigue life f composites, and formulate smart antibacterial components which are activated in the oral environment only when needed.
|Sun, Jirun; Watson, Stephanie S; Allsopp, David A et al. (2016) Tuning photo-catalytic activities of TiO2 nanoparticles using dimethacrylate resins. Dent Mater 32:363-72|
|Hollingsworth, Javoris V; Bhupathiraju, N V S Dinesh K; Sun, Jirun et al. (2016) Preparation of Metalloporphyrin-Bound Superparamagnetic Silica Particles via ""Click"" Reaction. ACS Appl Mater Interfaces 8:792-801|
|Huyang, George; Debertin, Anne E; Sun, Jirun (2016) Design and development of self-healing dental composites. Mater Des 94:295-302|
|Gonzalez-Bonet, Andres; Kaufman, Gili; Yang, Yin et al. (2015) Preparation of Dental Resins Resistant to Enzymatic and Hydrolytic Degradation in Oral Environments. Biomacromolecules 16:3381-8|
|Wang, Ping; Liu, Xian; Zhao, Liang et al. (2015) Bone tissue engineering via human induced pluripotent, umbilical cord and bone marrow mesenchymal stem cells in rat cranium. Acta Biomater 18:236-48|
|Hoffman, Kathleen; Skrtic, Drago; Sun, Jirun et al. (2015) Airbrushed composite polymer Zr-ACP nanofiber scaffolds with improved cell penetration for bone tissue regeneration. Tissue Eng Part C Methods 21:284-91|