Pressure to improve quality and lower cost of health cre has created the need to understand the effectiveness of medical interventions, such as gastrointestinal (GI) endoscopy. Despite widespread use of endoscopic procedures, very little is known about endoscopic practice patterns and patient outcomes in community-based settings. The ideal method for studying endoscopic procedures is to go directly to the source: the endoscopy report. With the advent of computerized databases, it is now possible to generate endoscopic reports while simultaneously creating a data file. We have developed a network of GI specialists in diverse practice settings who utilize a common computerized endoscopic report generator. Endoscopic data from these Clinical Affiliates is transmitted electronically to a centralized data repository and merged with data from multiple Clinical Affiliates for analysis. These merged data can then be used to examine practice patterns and address important research questions. Based on extensive experience in building a clinical network for endoscopic research our group is unique able to meet the requirements stipulated in the current proposal. The primary goal of this proposal is to use the existing endoscopic database to acquire information that will improve the quality of clinical practice in gastroenterology.
The specific aims of this proposal are to use the endoscopic database to: . Perform descriptive analyses of utilization, frequency and severity of endoscopic findings, practice patterns, practice variation (geographic region, type of clinical practice), and patient demographics (age, gender, race). . Use descriptive analyses to form the basis for developing hypotheses and risk stratification. . Observe the natural history of chronic GI diseases, and determine appropriate intervals for surveillance. . Determine the success and effectiveness of endoscopic therapies and new endoscopic innovations. . Determine the impact of endoscopic diagnoses and therapies on patient outcomes. . Evaluate the frequency of endoscopic complications, and risk factors for complications. . Use the database for specific research projects and to create patient registries for clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK057132-05
Application #
6647704
Study Section
Special Emphasis Panel (ZDK1-GRB-C (O1))
Program Officer
Everhart, James
Project Start
1999-09-30
Project End
2004-09-14
Budget Start
2003-09-01
Budget End
2004-09-14
Support Year
5
Fiscal Year
2003
Total Cost
$884,778
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Mooers, Harrison M; Holub, Jennifer L; Lieberman, David A (2018) Screening Women Aged 50-59 for CRC Using Fecal Occult Blood Test Produces Outcomes Similar to Men Undergoing Screening Colonoscopy. Dig Dis Sci 63:2780-2785
Kluge, Matthew A; Williams, J Lucas; Wu, Connie K et al. (2018) Inadequate Boston Bowel Preparation Scale scores predict the risk of missed neoplasia on the next colonoscopy. Gastrointest Endosc 87:744-751
Holub, Jennifer L; Morris, Cynthia; Fagnan, Lyle J et al. (2018) Quality of Colonoscopy Performed in Rural Practice: Experience From the Clinical Outcomes Research Initiative and the Oregon Rural Practice-Based Research Network. J Rural Health 34 Suppl 1:s75-s83
Lin, Emery C; Holub, Jennifer; Lieberman, David et al. (2018) Low Prevalence of Suspected Barrett's Esophagus in Patients with Gastroesophageal Reflux Disease Without Alarm Symptoms. Clin Gastroenterol Hepatol :
Woodward, Zibing; Williams, J Lucas; Sonnenberg, Amnon (2016) Length of endoscopic workup in gastrointestinal bleeding. Eur J Gastroenterol Hepatol 28:1166-71
Saks, Karen; Enestvedt, Brintha K; Holub, Jennifer L et al. (2016) Colonoscopy Identifies Increased Prevalence of Large Polyps or Tumors in Patients 40-49 Years Old With Hematochezia vs Other Gastrointestinal Indications. Clin Gastroenterol Hepatol 14:843-849
Thakkar, Kalpesh; Holub, Jennifer L; Gilger, Mark A et al. (2016) Quality indicators for pediatric colonoscopy: results from a multicenter consortium. Gastrointest Endosc 83:533-41
Day, Lukejohn W; Nazareth, Michelle; Sewell, Justin L et al. (2015) Practice variation in PEG tube placement: trends and predictors among providers in the United States. Gastrointest Endosc 82:37-45
Childers, Ryan E; Williams, J Lucas; Sonnenberg, Amnon (2015) Practice patterns of sedation for colonoscopy. Gastrointest Endosc 82:503-11
Lieberman, David A; Holub, Jennifer L; Morris, Cynthia D et al. (2014) Low rate of large polyps (>9 mm) within 10 years after an adequate baseline colonoscopy with no polyps. Gastroenterology 147:343-50

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