Between 2002-2012, the NIDDK sponsored Phases 1 and 2 of the prospective Chronic Renal Insufficiency Cohort (CRIC) Study, which enrolled >3,900 adults with chronic kidney disease at seven Clinical Centers to address the overarching goals of identifying risk factors for kidney disease progression and clarifying the relationship between renal dysfunction and the risks of subclinical and clinical cardiovascular events, death, and resource utilization. The initial five-year follow-up of Phase 1 was extended by an additional five years in Phase 2, which ends April 2013. The proposed CRIC-Phase 3 offers a unique opportunity to leverage the existing effort and success of CRIC by extending the follow-up for the existing cohort to June 2018;by recruiting and following a new cohort of 1,500 individuals with less severe CKD;and by evaluating a more comprehensive set of exposures and outcomes. CRIC-Phase 3 will become an unparalleled resource that will expand the science related to chronic kidney disease natural history as well as the impact of kidney dysfunction on the development and progression of cardiovascular disease and other adverse events.
Specific Aims to be addressed by the Kaiser Permanente Northern California/University of California, San Francisco Clinical Center are: 1. To re-enroll a high percentage of CRIC-Phase 1 participants into CRIC-Phase 3. 2. To recruit and enroll an additional cohort of 215 participants with less severe CKD into CRIC-Phase 3. 3. To collect exposure and outcome data per the CRIC-Phase 3 protocol.4.To maintain high levels of retention in the study. 5. To investigate clinical events and obtain supporting medical records and documentation. 6. To enter data and process/ship biological specimens. 7. To implement local quality assurance and quality control procedures as a means to obtain standardized, high quality measurements. 8. To monitor data collection, data entry, and follow-up rates. 9. To participate in governance and oversight of CRIC through study-wide subcommittees and activities. 10. To publish and present findings from the CRIC Study. 11. To promote and support the conduct of ancillary studies in CRIC, including collaboration with the broader nephrology research community.

Public Health Relevance

Chronic kidney disease has a significant public health impact on the US population and currently affects an estimated 26 million Americans. The NIDDK-sponsored Chronic Renal Insufficiency Cohort (CRIC) Study was established to identify factors leading to worsening of chronic kidney disease and to understand the complex relationship between kidney dysfunction, cardiovascular disease, death, and other clinical and patient-centered outcomes. The overall purpose of the proposed project is to extend the follow-up of the existing CRIC Study cohort of >3,900 adults with chronic kidney disease and to augment and expand CRIC by recruiting an additional 1,500 adults with milder CKD to follow for up to five years.

Agency
National Institute of Health (NIH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK060902-14
Application #
8722531
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kusek, John W
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94612
Rahman, Mahboob; Yang, Wei; Akkina, Sanjeev et al. (2014) Relation of serum lipids and lipoproteins with progression of CKD: The CRIC study. Clin J Am Soc Nephrol 9:1190-8
Scialla, Julia J; Xie, Huiliang; Rahman, Mahboob et al. (2014) Fibroblast growth factor-23 and cardiovascular events in CKD. J Am Soc Nephrol 25:349-60
Bansal, Nisha; Fan, Dongjie; Hsu, Chi-Yuan et al. (2014) Incident atrial fibrillation and risk of death in adults with chronic kidney disease. J Am Heart Assoc 3:e001303
Ricardo, Ana C; Yang, Wei; Lora, Claudia M et al. (2014) Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study. Clin Nephrol 81:30-7
Chirinos, Julio A; Khan, Abigail; Bansal, Nisha et al. (2014) Arterial stiffness, central pressures, and incident hospitalized heart failure in the chronic renal insufficiency cohort study. Circ Heart Fail 7:709-16
Lowrance, William T; OrdoƱez, Juan; Udaltsova, Natalia et al. (2014) CKD and the risk of incident cancer. J Am Soc Nephrol 25:2327-34
Mariani, Laura H; White, Matthew T; Shults, Justine et al. (2014) Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. J Ren Nutr 24:186-93
Wing, Maria R; Devaney, Joseph M; Joffe, Marshall M et al. (2014) DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 29:864-72
Bansal, Nisha; Hsu, Chi-yuan; Go, Alan S (2014) Intersection of cardiovascular disease and kidney disease: atrial fibrillation. Curr Opin Nephrol Hypertens 23:275-82
Yang, Wei; Xie, Dawei; Anderson, Amanda H et al. (2014) Association of kidney disease outcomes with risk factors for CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis 63:236-43

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