Between 2002-2006, the prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled 3939 adults with chronic kidney disease (CKD) to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events, death, and resource utilization. The proposed Phase III of CRIC, which extends follow-up through 2018, offers a unique opportunity to leverage the existing effort and success of CRIC to establish a cohort of participants with CKD who have long-term prospective follow-up on progression of kidney disease and a variety of different outcomes. This unparalleled resource will also expand the science related to CKD natural history as well as the impact on cardiovascular disease and other adverse events. This application is submitted in response to RFA-DK-12-508, """"""""Limited Competition: Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01),"""""""" on behalf of the University of Illinois at Chicago (UIC) Clinical Center. During the first two phases of the CRIC Study, the UIC Clinical Center research team has been successful in terms of recruitment, retention, protocol implementation, data quality, and scientific productivity. Noteworthy achievements at UIC have included a strong focus on heath disparities in CKD, a significant number of UIC investigator-led publications, and the promotion of new physician-scientists. In addition, the UIC investigators have successfully leveraged the CRIC infrastructure to secure a number of funded ancillary studies including the Hispanic CRIC Study (R01DK072231, Lash), Sleep as a Novel Risk Factor in CKD (R01DK071696, Van Cauter), a Midcareer Investigator Award in Patient-Oriented Research (K24, DK092290, Lash), a K23 Career Development Award (K23DK091313, Lora), a Diversity Supplement (Ricardo), and a Fogarty International Research Collaboration Award (R03TW009441, Lash).

Public Health Relevance

The prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled 3939 adults with chronic kidney disease (CKD) to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney disease and the risks of cardiovascular events, death, and resource utilization. This application for Phase III of CRIC, which extends follow-up through 2018, is submitted by the University of Illinois at Chicago (UIC) Clinical Center and offers a unique opportunity to leverage the existing effort and success of CRIC to establish a cohort of participants with CKD who have long-term prospective follow-up on progression of kidney disease and a variety of different outcomes. During the first two phases of the CRIC Study, the UIC Clinical Center research team has been successful in terms of recruitment, retention, protocol implementation, data quality, a strong focus on heath disparities in CKD, a significant number of UIC investigator-led publications, and the promotion of new physician-scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01DK060980-13
Application #
8582269
Study Section
Special Emphasis Panel (ZDK1-GRB-N (M1))
Program Officer
Kusek, John W
Project Start
2001-09-28
Project End
2018-04-30
Budget Start
2013-08-19
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$635,000
Indirect Cost
$226,626
Name
University of Illinois at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Inker, Lesley A; Tighiouart, Hocine; Coresh, Josef et al. (2016) GFR Estimation Using β-Trace Protein and β2-Microglobulin in CKD. Am J Kidney Dis 67:40-8
Ricardo, Ana C; Roy, Jason A; Tao, Kaixiang et al. (2016) Influence of Nephrologist Care on Management and Outcomes in Adults with Chronic Kidney Disease. J Gen Intern Med 31:22-9
Kurella Tamura, Manjula; Vittinghoff, Eric; Yang, Jingrong et al. (2016) Anemia and risk for cognitive decline in chronic kidney disease. BMC Nephrol 17:13
Deo, Rajat; Shou, Haochang; Soliman, Elsayed Z et al. (2016) Electrocardiographic Measures and Prediction of Cardiovascular and Noncardiovascular Death in CKD. J Am Soc Nephrol 27:559-69
Drawz, Paul E; Alper, Arnold B; Anderson, Amanda H et al. (2016) Masked Hypertension and Elevated Nighttime Blood Pressure in CKD: Prevalence and Association with Target Organ Damage. Clin J Am Soc Nephrol 11:642-52
Hsu, Raymond K; Chai, Boyang; Roy, Jason A et al. (2016) Abrupt Decline in Kidney Function Before Initiating Hemodialysis and All-Cause Mortality: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 68:193-202
Denburg, Michelle R; Hoofnagle, Andrew N; Sayed, Samir et al. (2016) Comparison of Two ELISA Methods and Mass Spectrometry for Measurement of Vitamin D-Binding Protein: Implications for the Assessment of Bioavailable Vitamin D Concentrations Across Genotypes. J Bone Miner Res 31:1128-36
Tangri, Navdeep; Grams, Morgan E; Levey, Andrew S et al. (2016) Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis. JAMA 315:164-74
Amdur, Richard L; Feldman, Harold I; Gupta, Jayanta et al. (2016) Inflammation and Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol 11:1546-56
Gutiérrez, Orlando M; Parsa, Afshin; Isakova, Tamara et al. (2016) Genetic African Ancestry and Markers of Mineral Metabolism in CKD. Clin J Am Soc Nephrol 11:653-62

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