Between 2002-2006, the prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled 3939 adults with chronic kidney disease (CKD) to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events, death, and resource utilization. The proposed Phase III of CRIC, which extends follow-up through 2018, offers a unique opportunity to leverage the existing effort and success of CRIC to establish a cohort of participants with CKD who have long-term prospective follow-up on progression of kidney disease and a variety of different outcomes. This unparalleled resource will also expand the science related to CKD natural history as well as the impact on cardiovascular disease and other adverse events. This application is submitted in response to RFA-DK-12-508, """"""""Limited Competition: Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01),"""""""" on behalf of the University of Illinois at Chicago (UIC) Clinical Center. During the first two phases of the CRIC Study, the UIC Clinical Center research team has been successful in terms of recruitment, retention, protocol implementation, data quality, and scientific productivity. Noteworthy achievements at UIC have included a strong focus on heath disparities in CKD, a significant number of UIC investigator-led publications, and the promotion of new physician-scientists. In addition, the UIC investigators have successfully leveraged the CRIC infrastructure to secure a number of funded ancillary studies including the Hispanic CRIC Study (R01DK072231, Lash), Sleep as a Novel Risk Factor in CKD (R01DK071696, Van Cauter), a Midcareer Investigator Award in Patient-Oriented Research (K24, DK092290, Lash), a K23 Career Development Award (K23DK091313, Lora), a Diversity Supplement (Ricardo), and a Fogarty International Research Collaboration Award (R03TW009441, Lash).

Public Health Relevance

The prospective Chronic Renal Insufficiency Cohort (CRIC) Study enrolled 3939 adults with chronic kidney disease (CKD) to address overarching goals of identifying predictors of rapid progression of kidney disease and clarifying the relationship between kidney disease and the risks of cardiovascular events, death, and resource utilization. This application for Phase III of CRIC, which extends follow-up through 2018, is submitted by the University of Illinois at Chicago (UIC) Clinical Center and offers a unique opportunity to leverage the existing effort and success of CRIC to establish a cohort of participants with CKD who have long-term prospective follow-up on progression of kidney disease and a variety of different outcomes. During the first two phases of the CRIC Study, the UIC Clinical Center research team has been successful in terms of recruitment, retention, protocol implementation, data quality, a strong focus on heath disparities in CKD, a significant number of UIC investigator-led publications, and the promotion of new physician-scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK060980-14
Application #
8722533
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kusek, John W
Project Start
2001-09-28
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Grams, Morgan E; Yang, Wei; Rebholz, Casey M et al. (2017) Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 70:337-346
Mehta, Rupal; Cai, Xuan; Hodakowski, Alexander et al. (2017) Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study. Clin J Am Soc Nephrol 12:1795-1803
Xie, Dawei; Yang, Wei; Jepson, Christopher et al. (2017) Statistical Methods for Modeling Time-Updated Exposures in Cohort Studies of Chronic Kidney Disease. Clin J Am Soc Nephrol 12:1892-1899
Ricardo, Ana C; Goh, Vivien; Chen, Jinsong et al. (2017) Association of Sleep Duration, Symptoms, and Disorders with Mortality in Adults with Chronic Kidney Disease. Kidney Int Rep 2:866-873
Roy, Jason; Shou, Haochang; Xie, Dawei et al. (2017) Statistical Methods for Cohort Studies of CKD: Prediction Modeling. Clin J Am Soc Nephrol 12:1010-1017
Zhan, Min; St Peter, Wendy L; Doerfler, Rebecca M et al. (2017) Patterns of NSAIDs Use and Their Association with Other Analgesic Use in CKD. Clin J Am Soc Nephrol 12:1778-1786
Snitker, Soren; Doerfler, Rebecca M; Soliman, Elsayed Z et al. (2017) Association of QT-Prolonging Medication Use in CKD with Electrocardiographic Manifestations. Clin J Am Soc Nephrol :
Inker, Lesley A; Coresh, Josef; Sang, Yingying et al. (2017) Filtration Markers as Predictors of ESRD and Mortality: Individual Participant Data Meta-Analysis. Clin J Am Soc Nephrol 12:69-78
Chen, Jing; Budoff, Matthew J; Reilly, Muredach P et al. (2017) Coronary Artery Calcification and Risk of Cardiovascular Disease and Death Among Patients With Chronic Kidney Disease. JAMA Cardiol 2:635-643
Park, Meyeon; Hsu, Chi-Yuan; Go, Alan S et al. (2017) Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study. Clin J Am Soc Nephrol 12:761-771

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