This is an application from the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania to serve as the Scientific and Data Coordinating Center (SDCC) for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study. Chronic renal insufficiency (CRI) affects over 20 million Americans with particular burden among older adults. The morbidity associated with chronic kidney disease (CKD) derives from frequent progression to end-stage renal disease (ESRD), a disproportionate risk of cardiovascular events, and other morbidities associated with disability and high costs of care. A set of etiological factors is being identified as potentially responsible for both progressive renal disease and morbidities in the setting of CKD, especially those operating early in the course of CKD when progression may be forestalled. These factors include clinical, behavioral, and those associated with biomarkers. Characterizing relationships between these risk factors and outcomes will permit development of instruments to predict poor outcomes in patients with CRI and enhance understanding of the etiological mechanisms leading to these outcomes. Improved prediction will allow identification of high-risk subgroups with CRI, thus guiding enrollment into preventive treatment trials and application of preventive therapies. The proposed third phase of CRIC will combine the study of these current CRIC participants along with 1,500 additional study participants to address overarching goals of understanding the relationship between kidney disease and the risks of cardiovascular and other types of morbidity. In particular, during Phase III, CRIC's SDCC will continue to provide scientific, data analytical, and logistical support to the CRIC Research Network as it continues to address a diverse set of high-impact areas of investigation with expanded emphasis on CKD in older adults, patients with moderate levels of CKD, and the burden of morbidity in patients with CKD. The CRIC Study cohort is an unparalleled resource that will also expand our ability to conduct science related to CKD through additional collaborations throughout the renal research community and interactions with other epidemiologic studies worldwide.

Public Health Relevance

The CRIC Study is a national multi-center evaluation of the factors associated with progression of disease within a diverse population of Americans with varied forms of chronic kidney disease (CKD). In addition to examining the progression of kidney disease the CRIC Study focuses on other health consequences within the CKD population. The study's focus spans from mechanistic pathways of disease to health behavior and lifestyle factors relevant to the experience of individuals with CKD.

National Institute of Health (NIH)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kusek, John W
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Biostatistics & Other Math Sci
Schools of Medicine
United States
Zip Code
Yang, Wei; Xie, Dawei; Anderson, Amanda H et al. (2014) Association of kidney disease outcomes with risk factors for CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis 63:236-43
Wing, Maria R; Yang, Wei; Teal, Valerie et al. (2014) Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring) 22:1359-66
Grunwald, Juan E; Pistilli, Maxwell; Ying, Gui-Shuang et al. (2014) Retinopathy and progression of CKD: The CRIC study. Clin J Am Soc Nephrol 9:1217-24
Deo, Rajat; Yang, Wei; Khan, Abigail M et al. (2014) Serum aldosterone and death, end-stage renal disease, and cardiovascular events in blacks and whites: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Hypertension 64:103-10
Yaffe, Kristine; Kurella-Tamura, Manjula; Ackerson, Lynn et al. (2014) Higher levels of cystatin C are associated with worse cognitive function in older adults with chronic kidney disease: the chronic renal insufficiency cohort cognitive study. J Am Geriatr Soc 62:1623-9
Rahman, Mahboob; Yang, Wei; Akkina, Sanjeev et al. (2014) Relation of serum lipids and lipoproteins with progression of CKD: The CRIC study. Clin J Am Soc Nephrol 9:1190-8
Bachmann, Lorin M; Nilsson, Goran; Bruns, David E et al. (2014) State of the art for measurement of urine albumin: comparison of routine measurement procedures to isotope dilution tandem mass spectrometry. Clin Chem 60:471-80
Scialla, Julia J; Xie, Huiliang; Rahman, Mahboob et al. (2014) Fibroblast growth factor-23 and cardiovascular events in CKD. J Am Soc Nephrol 25:349-60
Ricardo, Ana C; Yang, Wei; Lora, Claudia M et al. (2014) Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study. Clin Nephrol 81:30-7
Chirinos, Julio A; Khan, Abigail; Bansal, Nisha et al. (2014) Arterial stiffness, central pressures, and incident hospitalized heart failure in the chronic renal insufficiency cohort study. Circ Heart Fail 7:709-16

Showing the most recent 10 out of 41 publications