The competing renewal application is for the German Clinic Center of The Environmental;Determinants of Diabetes in the Young (TEDDY) study. The primary objective of this multi-center, multi-national, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression, or with protection from the development of T1DM will also be identified. TEDDY is an observational cohort study in which newborns who are less than 4 months of age and have high risk HLA alleles in the general population or are first-degree relatives of patients affected with T1DM will be enrolled. Six Clinical Centers in the United States and Europe will screen 361,588 newborns of which it is anticipated that 17,804 will be eligible for enrollment with just over 7,800 followed. Recruitment stared in September of 2004 and will continue until December 31, 2009. Participants will be followed to age 15 years. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1DM.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK063836-10
Application #
8294369
Study Section
Special Emphasis Panel (ZDK1-GRB-G (J1))
Program Officer
Spain, Lisa M
Project Start
2003-04-01
Project End
2013-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
10
Fiscal Year
2012
Total Cost
$321,319
Indirect Cost
$41,177
Name
Forschergruppe Diabetes E. V.
Department
Type
DUNS #
319649778
City
Munich/Neuherberg
State
Country
Germany
Zip Code
85764
Uusitalo, Ulla; Liu, Xiang; Yang, Jimin et al. (2016) Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA Pediatr 170:20-8
Sharma, Ashok; Liu, Xiang; Hadley, David et al. (2016) Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLoS One 11:e0152476
Yang, Jimin; Lynch, Kristian F; Uusitalo, Ulla M et al. (2016) Factors associated with longitudinal food record compliance in a paediatric cohort study. Public Health Nutr 19:804-13
Törn, Carina; Liu, Xiang; Hagopian, William et al. (2016) Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. Sci Rep 6:27887
Johnson, Suzanne Bennett; Lynch, Kristian F; Baxter, Judith et al. (2016) Predicting Later Study Withdrawal in Participants Active in a Longitudinal Birth Cohort Study for 1 Year: The TEDDY Study. J Pediatr Psychol 41:373-83
Andrén Aronsson, Carin; Lee, Hye-Seung; Koletzko, Sibylle et al. (2016) Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol 14:403-409.e3
Haghighi, Mona; Johnson, Suzanne Bennett; Qian, Xiaoning et al. (2016) A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Sci Rep 6:30828
Swartling, Ulrica; Lynch, Kristian; Smith, Laura et al. (2016) Parental Estimation of Their Child's Increased Type 1 Diabetes Risk During the First 2 Years of Participation in an International Observational Study: Results From the TEDDY study. J Empir Res Hum Res Ethics 11:106-14
Vehik, Kendra; Lynch, Kristian F; Schatz, Desmond A et al. (2016) Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study. Diabetes Care 39:1535-42
Elding Larsson, Helena; Vehik, Kendra; Haller, Michael J et al. (2016) Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study. Diabetes 65:1988-95

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