This limited competition renewal application is for the Turku/Finland Clinical Center of The Environmental Determinants of Diabates in the Young (TEDDY) study. The primary objective of this multi-center, multi- national epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of islet autoimmunity and type 1 diabates mellitus (T1D). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression, or which provide protection from the development of T1D will also be identified. TEDDY is an observational cohort study in which newborns who are less than 4.5 months of age and have high risk HLA genotypes and come from the general population, or carry HLA risk alleles and are first-degree relatives of patients affected with T1D will be enrolled. Six Clinical Centers in the United States and Europe will screen 361,588 newborns of which it is anticipated that 17,804 will be eligible for enrollment, with just over 7,800 followed. Recruitment started in September 2004 and will continue until December 31, 2009. Participants will be followed to the age of 15 years. Identification of such etiologically important factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1D.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project--Cooperative Agreements (U01)
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Study Section
Special Emphasis Panel (ZDK1-GRB-G (J1))
Program Officer
Spain, Lisa M
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Hospital District of Southwest Finland
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Yang, J; Lernmark, Å; Uusitalo, U M et al. (2014) Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. Int J Obes (Lond) 38:1491-6
Johnson, Suzanne Bennett; Lynch, Kristian F; Lee, Hye-Seung et al. (2014) At high risk for early withdrawal: using a cumulative risk model to increase retention in the first year of the TEDDY study. J Clin Epidemiol 67:609-11
Smith, Laura B; Lynch, Kristian F; Baxter, Judith et al. (2014) Factors associated with maternal-reported actions to prevent type 1 diabetes in the first year of the TEDDY study. Diabetes Care 37:325-31
Hummel, Sandra; Vehik, Kendra; Uusitalo, Ulla et al. (2014) Infant feeding patterns in families with a diabetes history - observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study. Public Health Nutr 17:2853-62
Elding Larsson, Helena; Vehik, Kendra; Gesualdo, Patricia et al. (2014) Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr Diabetes 15:118-26
Liu, Edwin; Lee, Hye-Seung; Aronsson, Carin A et al. (2014) Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med 371:42-9
Vehik, Kendra; Fiske, Steven W; Logan, Chad A et al. (2013) Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY. Diabetes Metab Res Rev 29:557-67
Hagopian, William A; Erlich, Henry; Lernmark, Ake et al. (2011) The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes 12:733-43
Elding Larsson, Helena; Vehik, Kendra; Bell, Ronny et al. (2011) Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up. Diabetes Care 34:2347-52
Ziegler, Anette-G; Pflueger, Maren; Winkler, Christiane et al. (2011) Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. J Autoimmun 37:3-7

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