The UNC-Chapel Hill clinical center has been a leader in the Drug-Induced Liver Injury network (DILIN) from its inception, in terms of subject recruitment, data quality, biospecimen collection, and ancillary study proposals. Dr. Paul Watkins has served as chair of the DILIN Steering Committee and has led national efforts to publicize the network and identify non-profit and corporate partners. Prospects for continued leadership in the proposed 5-year cycle have been bolstered by the inclusion of Dr. Herbert Bonkovsky, who moved last year from the University of Connecticut where he was PI of DILIN clinical site, to become vice president for research at the Carolinas Medical Center, Charlotte. Dr. Bonkovsky has maintained his leadership roles within the DILIN and has recently established the Carolinas Medical Center as a very successful DILIN recruitment site for western North Carolina. Incorporating the Carolinas Medical Center site, capitalizing on community research networks to be established by our Clinical and Translational Science Award, and expanding current referral networks will allow us to double our subject recruitment rate. We will continue to lead the network in proposing and executing ancillary studies through collaborations with researchers from UNC and at neighboring institutions, such as Duke, the Environmental Protection Agency, the National Institutes of Environmental Health Sciences, and the Hamner Institute for Health Sciences. Our experienced investigator team is dedicated to establishing an authoritative, complete and current internet website devoted to drug-induced liver injury (DILI). Finally, we will work diligently to develop and validate a simple and practical web-based instrument that will become the preferred means to establish the diagnosis of DILI.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK065201-09
Application #
8132865
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O1))
Program Officer
Serrano, Jose
Project Start
2003-09-30
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
9
Fiscal Year
2011
Total Cost
$315,971
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Nicoletti, Paola; Aithal, Guruprasad P; Bjornsson, Einar S et al. (2017) Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study. Gastroenterology 152:1078-1089
Church, Rachel J; Watkins, Paul B (2017) The transformation in biomarker detection and management of drug-induced liver injury. Liver Int 37:1582-1590
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Whritenour, Jessica; Ko, Mira; Zong, Qing et al. (2017) Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response. J Immunotoxicol 14:31-38
Russo, Mark W; Steuerwald, Nury; Norton, Harry J et al. (2017) Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance. Liver Int 37:757-764
Ahmad, Jawad; Odin, Joseph A; Hayashi, Paul H et al. (2017) Identification and Characterization of Fenofibrate-Induced Liver Injury. Dig Dis Sci 62:3596-3604
de Boer, Ynto S; Kosinski, Andrzej S; Urban, Thomas J et al. (2017) Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury. Clin Gastroenterol Hepatol 15:103-112.e2
Chalasani, Naga; Reddy, K Rajender K; Fontana, Robert J et al. (2017) Idiosyncratic Drug Induced Liver Injury in African-Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians. Am J Gastroenterol 112:1382-1388

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