The UNC-Chapel Hill clinical center has been a leader in the Drug-Induced Liver Injury network (DILIN) from its inception, in terms of subject recruitment, data quality, biospecimen collection, and ancillary study proposals. Dr. Paul Watkins has served as chair of the DILIN Steering Committee and has led national efforts to publicize the network and identify non-profit and corporate partners. Prospects for continued leadership in the proposed 5-year cycle have been bolstered by the inclusion of Dr. Herbert Bonkovsky, who moved last year from the University of Connecticut where he was PI of DILIN clinical site, to become vice president for research at the Carolinas Medical Center, Charlotte. Dr. Bonkovsky has maintained his leadership roles within the DILIN and has recently established the Carolinas Medical Center as a very successful DILIN recruitment site for western North Carolina. Incorporating the Carolinas Medical Center site, capitalizing on community research networks to be established by our Clinical and Translational Science Award, and expanding current referral networks will allow us to double our subject recruitment rate. We will continue to lead the network in proposing and executing ancillary studies through collaborations with researchers from UNC and at neighboring institutions, such as Duke, the Environmental Protection Agency, the National Institutes of Environmental Health Sciences, and the Hamner Institute for Health Sciences. Our experienced investigator team is dedicated to establishing an authoritative, complete and current internet website devoted to drug-induced liver injury (DILI). Finally, we will work diligently to develop and validate a simple and practical web-based instrument that will become the preferred means to establish the diagnosis of DILI.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK065201-10
Application #
8330952
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O1))
Program Officer
Serrano, Jose
Project Start
2003-09-30
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2012
Total Cost
$295,438
Indirect Cost
$83,409
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Zheng, Elizabeth X; Rossi, Simona; Fontana, Robert J et al. (2016) Risk of Liver Injury Associated with Green Tea Extract in SLIMQUICK(®) Weight Loss Products: Results from the DILIN Prospective Study. Drug Saf 39:749-54
Hayashi, Paul H; Fontana, Robert J; Chalasani, Naga P et al. (2015) Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity. Clin Gastroenterol Hepatol 13:1676-82.e1
Seeff, Leonard B; Bonkovsky, Herbert L; Navarro, Victor J et al. (2015) Herbal products and the liver: a review of adverse effects and mechanisms. Gastroenterology 148:517-532.e3
Martinez, Melissa A; Vuppalanchi, Raj; Fontana, Robert J et al. (2015) Clinical and histologic features of azithromycin-induced liver injury. Clin Gastroenterol Hepatol 13:369-376.e3
Besur, Siddesh; Schmeltzer, Paul; Bonkovsky, Herbert L (2015) Acute Porphyrias. J Emerg Med 49:305-12

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