The University of North Carolina-Chapel HIll (UNC) Clinical Center leads the eight Drug-Induced Liver Injury Network (DILIN) centers in terms of total subject recruitment and number of ancillary studies proposed and conducted. Dr. Paul Watkins has served as chair of the Steering Committee since 2003, when the network was created. Dr. Herbert Bonkovsky was PI at University of Connecticut, one of the original DILIN clinical sites, and since joining the UNC Clinical Center, he has continued to be very active in subject recruitment, ancillary study execution, and general guidance for the network. Dr. Paul Hayashi serves as co-chair of the network's Causality Assessment Committee. In addition to continuing in these administrative roles, we proposed to enroll at least 75 percent of DILIN subjects within 15 days of the initial health care encounter and to continue to lead the network in total subject recruitment (Specific Aim 1). We will work with DILIN investigators to further develop the LiverTox website and to create within it a new DILI diagnostic instrument that is accurate, simple, and practical for clinicians (Specific Aim 2). Finally, we propose conducting DILIN ancillary studies by utilizing fully the research infrastructure and international collaborations we have built specifically for this purpose (Specific Aim 3). With this funding, we believe the UNC Clinical Center would be well positioned to capitalize on the unprecedented resources we would help to develop within DILIN to achieve a level of mechanistic understanding that could revolutionize the diagnosis and management of DILI.

Public Health Relevance

Drug-induced liver injury remains the major adverse event that results in regulatory actions that prevent important new drugs from helping patients. The data and tissue banks created by the DILIN network provide the needed resources to solve this important public health problem.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
4U01DK065201-14
Application #
9132246
Study Section
Special Emphasis Panel (ZDK1-GRB-N (M7)S)
Program Officer
Serrano, Jose
Project Start
2003-09-30
Project End
2018-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
14
Fiscal Year
2016
Total Cost
$307,359
Indirect Cost
$100,215
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Bonkovsky, Herbert L; Barnhart, Huiman X; Foureau, David M et al. (2018) Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. PLoS One 13:e0206389
Dakhoul, Lara; Ghabril, Marwan; Gu, Jiezhun et al. (2018) Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers. Clin Gastroenterol Hepatol 16:722-729.e2
Ahmad, Jawad; Rossi, Simona; Rodgers, Shuchi K et al. (2018) Sclerosing Cholangitis-Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury. Clin Gastroenterol Hepatol :
Church, Rachel J; Kullak-Ublick, Gerd A; Aubrecht, Jiri et al. (2018) Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort. Hepatology :
Bonkovsky, Herbert L; Kleiner, David E; Gu, Jiezhun et al. (2017) Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements. Hepatology 65:1267-1277
Nicoletti, Paola; Aithal, Guruprasad P; Bjornsson, Einar S et al. (2017) Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study. Gastroenterology 152:1078-1089
Hayashi, Paul H; Rockey, Don C; Fontana, Robert J et al. (2017) Death and liver transplantation within 2 years of onset of drug-induced liver injury. Hepatology 66:1275-1285
Navarro, Victor J; Khan, Ikhlas; Björnsson, Einar et al. (2017) Liver injury from herbal and dietary supplements. Hepatology 65:363-373
Russo, Mark W; Steuerwald, Nury; Norton, Harry J et al. (2017) Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance. Liver Int 37:757-764
Ahmad, Jawad; Odin, Joseph A; Hayashi, Paul H et al. (2017) Identification and Characterization of Fenofibrate-Induced Liver Injury. Dig Dis Sci 62:3596-3604

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