LABS was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese.
LABS aims to explore relationships of patient characteristics, clinical conditions, serologic and genetic markers, process of care, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS in its first 5 years have been to define the domains of exploration, identify appropriate metrics and enroll 5105 participants in LABS land achieve vital status data for 99% due for at 30 days post-surgery. In addition, 1947 participants in LABS 2 have been recruited with data collected for 91% for 6 months follow-up. An extension of LABS would build on the rigorous research infrastructure across 10 clinical sites at the 6 clinical centers representing several care delivery systems and patient populations. LABS enrolls patients from 6 academic and 4 community hospitals undergoing operations by 33 surgeons. These sites have created a cohort with considerable diversity of important patient characteristics. LABS includes 21% males (range across sites 16% to 32%), 9% Black/African-Americans (range 0% to 24%), 7% Hispanics (range 1% to 16%), 10% age 60+ years (range 5%-18%), and 10% BMI 60+ kg/m2 (range 6% to 27%). These features have been linked to short and long-term outcomes and represent critical subgroups that have not been adequately characterized because they appear infrequently in most single-center cohorts. Importantly, the diversity across sites is more likely to represent the bariatric surgery population in the U.S. than would be possible from any individual site.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK066526-08
Application #
8119120
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Horlick, Mary
Project Start
2003-09-30
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
8
Fiscal Year
2011
Total Cost
$509,464
Indirect Cost
Name
East Carolina University
Department
Surgery
Type
Schools of Medicine
DUNS #
607579018
City
Greenville
State
NC
Country
United States
Zip Code
27858
King, Wendy C; Chen, Jia-Yuh; Courcoulas, Anita P et al. (2017) Alcohol and other substance use after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1392-1402
King, Wendy C; Chen, Jia-Yuh; Belle, Steven H et al. (2017) Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1337-1346
Menke, Marie N; King, Wendy C; White, Gretchen E et al. (2017) Contraception and Conception After Bariatric Surgery. Obstet Gynecol 130:979-987
Alfonso-Cristancho, Rafael; King, Wendy C; Mitchell, James E et al. (2016) Longitudinal Evaluation of Work Status and Productivity After Bariatric Surgery. JAMA 316:1595-1597
Purnell, Jonathan Q; Selzer, Faith; Wahed, Abdus S et al. (2016) Type 2 Diabetes Remission Rates After Laparoscopic Gastric Bypass and Gastric Banding: Results of the Longitudinal Assessment of Bariatric Surgery Study. Diabetes Care 39:1101-7
King, Wendy C; Chen, Jia-Yuh; Courcoulas, Anita P et al. (2016) Objectively-measured sedentary time and cardiometabolic health in adults with severe obesity. Prev Med 84:12-8
Spitznagel, Mary Beth; Alosco, Michael; Inge, Thomas H et al. (2016) Adolescent weight history and adult cognition: before and after bariatric surgery. Surg Obes Relat Dis 12:1057-64
King, Wendy C; Chen, Jia-Yuh; Belle, Steven H et al. (2016) Change in Pain and Physical Function Following Bariatric Surgery for Severe Obesity. JAMA 315:1362-71
Mitchell, James E; Steffen, Kristine; Engel, Scott et al. (2015) Addictive disorders after Roux-en-Y gastric bypass. Surg Obes Relat Dis 11:897-905
Smith, Mark D; Adeniji, Abidemi; Wahed, Abdus S et al. (2015) Technical factors associated with anastomotic leak after Roux-en-Y gastric bypass. Surg Obes Relat Dis 11:313-20

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