LABS was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese.
LABS aims to explore relationships of patient characteristics, clinical conditions, serologic and genetic markers, process of care, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS in its first 5 years have been to define the domains of exploration, identify appropriate metrics and enroll 5105 participants in LABS land achieve vital status data for 99% due for at 30 days post-surgery. In addition, 1947 participants in LABS 2 have been recruited with data collected for 91% for 6 months follow-up. An extension of LABS would build on the rigorous research infrastructure across 10 clinical sites at the 6 clinical centers representing several care delivery systems and patient populations. LABS enrolls patients from 6 academic and 4 community hospitals undergoing operations by 33 surgeons. These sites have created a cohort with considerable diversity of important patient characteristics. LABS includes 21% males (range across sites 16% to 32%), 9% Black/African-Americans (range 0% to 24%), 7% Hispanics (range 1% to 16%), 10% age 60+ years (range 5%-18%), and 10% BMI 60+ kg/m2 (range 6% to 27%). These features have been linked to short and long-term outcomes and represent critical subgroups that have not been adequately characterized because they appear infrequently in most single-center cohorts. Importantly, the diversity across sites is more likely to represent the bariatric surgery population in the U.S. than would be possible from any individual site.

Public Health Relevance

(See Instructions): Critical scientific advantages of the multi-center LABS consortium compared to single-center studies include: 1) The ability to recruit a larger number of patients, in a comparable, or shorter, period of time and 2) A research infrastructure with rigorous data collection practices, high levels of data accuracy and completeness, rigorous follow-up, and a comprehensive database of clearly defined data elements.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK066526-09
Application #
8317685
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Horlick, Mary
Project Start
2003-09-30
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$449,727
Indirect Cost
$156,601
Name
East Carolina University
Department
Surgery
Type
Schools of Medicine
DUNS #
607579018
City
Greenville
State
NC
Country
United States
Zip Code
27858
Mitchell, James E; King, Wendy C; Courcoulas, Anita et al. (2015) Eating behavior and eating disorders in adults before bariatric surgery. Int J Eat Disord 48:215-22
Purnell, Jonathan Q; Selzer, Faith; Smith, Mark D et al. (2014) Metabolic syndrome prevalence and associations in a bariatric surgery cohort from the Longitudinal Assessment of Bariatric Surgery-2 study. Metab Syndr Relat Disord 12:86-94
Mitchell, James E; King, Wendy C; Chen, Jia-Yuh et al. (2014) Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study. Obesity (Silver Spring) 22:1799-806
Kleiner, David E; Berk, Paul D; Hsu, Jesse Y et al. (2014) Hepatic pathology among patients without known liver disease undergoing bariatric surgery: observations and a perspective from the longitudinal assessment of bariatric surgery (LABS) study. Semin Liver Dis 34:98-107
Christian, Nicholas J; King, Wendy C; Yanovski, Susan Z et al. (2013) Validity of self-reported weights following bariatric surgery. JAMA 310:2454-6
King, Wendy C; Kalarchian, Melissa A; Steffen, Kristine J et al. (2013) Associations between physical activity and mental health among bariatric surgical candidates. J Psychosom Res 74:161-9
Gourash, William F; Ebel, Faith; Lancaster, Kathy et al. (2013) Longitudinal Assessment of Bariatric Surgery (LABS): retention strategy and results at 24 months. Surg Obes Relat Dis 9:514-9
Khan, Akram; King, Wendy C; Patterson, Emma J et al. (2013) Assessment of obstructive sleep apnea in adults undergoing bariatric surgery in the longitudinal assessment of bariatric surgery-2 (LABS-2) study. J Clin Sleep Med 9:21-9
Courcoulas, Anita P; Christian, Nicholas J; Belle, Steven H et al. (2013) Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA 310:2416-25
King, Wendy C; Engel, Scott G; Elder, Katherine A et al. (2012) Walking capacity of bariatric surgery candidates. Surg Obes Relat Dis 8:48-59

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