LABS was conceived to address important issues in bariatric surgery and metabolism in adults, exploring relationships of patient characteristics, clinical conditions, serologic and genetic markers, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS have been establishing a research consortium and its infrastructure;defining domains of exploration, specific research questions and an effective study design to efficiently address those questions;identifying appropriate metrics;designing and implementing a web-based data collection system and an extensive database;completing a cohort of over 5000 participants to study the short-term safety of bariatric surgery;enrolling approximately 2000 participants into a 2400 person cohort intended to address longer term safety and efficacy;and implementing 2 substudies. The Data Coordinating Center (DCC) provides logistical and administrative support and expertise in database management, website construction and maintenance, computer systems, epidemiology, biostatistics, and methodology. During this proposed continuation of LABS, the DCC will continue to support the consortium in all aspects of study design, conduct, analysis, logistics, and administration. This includes maintaining the distributed data entry and database management systems;maintaining contact with the NIDDK-supported biospecimen and data repositories;administering a subcontract with a Central Laboratory if necessary;assisting the study pathologist with respect to biopsy specimen tracking and data collection;maintaining and improving the study website that has public, private, participant and systems areas;providing logistical support to the Clinical Centers, NIDDK Project Scientist, committees and subcommittees, central facilities, and Data and Safety Monitoring Board (DSMB);and analyzing and reporting study results to better inform the research and public communities regarding long-term outcomes following bariatric surgery. Obesity is a major public health problem expected to increase in the future. Bariatric surgery is currently the most effective long term therapy. This multi-center consortium was created to "facilitate coordinated clinical, epidemiological, and behavioral research in...bariatric surgery". The data coordinating center provides logistical and scientific support, and developed the core database.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK066557-10
Application #
8520288
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Horlick, Mary
Project Start
2003-09-30
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$1,055,812
Indirect Cost
$374,223
Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Mitchell, James E; King, Wendy C; Courcoulas, Anita et al. (2015) Eating behavior and eating disorders in adults before bariatric surgery. Int J Eat Disord 48:215-22
Purnell, Jonathan Q; Selzer, Faith; Smith, Mark D et al. (2014) Metabolic syndrome prevalence and associations in a bariatric surgery cohort from the Longitudinal Assessment of Bariatric Surgery-2 study. Metab Syndr Relat Disord 12:86-94
Mitchell, James E; King, Wendy C; Chen, Jia-Yuh et al. (2014) Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study. Obesity (Silver Spring) 22:1799-806
Jenkins, Todd M; Wilson Boyce, Tawny; Akers, Rachel et al. (2014) Evaluation of a Teleform-based data collection system: a multi-center obesity research case study. Comput Biol Med 49:15-8
Kleiner, David E; Berk, Paul D; Hsu, Jesse Y et al. (2014) Hepatic pathology among patients without known liver disease undergoing bariatric surgery: observations and a perspective from the longitudinal assessment of bariatric surgery (LABS) study. Semin Liver Dis 34:98-107
Christian, Nicholas J; King, Wendy C; Yanovski, Susan Z et al. (2013) Validity of self-reported weights following bariatric surgery. JAMA 310:2454-6
King, Wendy C; Kalarchian, Melissa A; Steffen, Kristine J et al. (2013) Associations between physical activity and mental health among bariatric surgical candidates. J Psychosom Res 74:161-9
Gourash, William F; Ebel, Faith; Lancaster, Kathy et al. (2013) Longitudinal Assessment of Bariatric Surgery (LABS): retention strategy and results at 24 months. Surg Obes Relat Dis 9:514-9
Khan, Akram; King, Wendy C; Patterson, Emma J et al. (2013) Assessment of obstructive sleep apnea in adults undergoing bariatric surgery in the longitudinal assessment of bariatric surgery-2 (LABS-2) study. J Clin Sleep Med 9:21-9
Courcoulas, Anita P; Christian, Nicholas J; Belle, Steven H et al. (2013) Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA 310:2416-25

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