The University of Washington (UW) Clinical Center has been a significant contributor in the LABS Consortium since its inception and currently recruits subjects for LABS2 study from two Seattle-area hospitals performing bariatric operations: the University of Washington Medical Center (UWMC) and Virginia Mason Medical Center (VMMC). We propose to complete LABS2 recruitment at the UW Clinical Center by 6/30/2009 and to extend longitudinal follow-up of the LABS2 cohort through 6/30/2014. As the second highest Clinical Center contributor to LABS2 surgeries, we anticipate follow-up of 520 LABS2 subjects annually. An observational, longitudinal study innately involves retention challenges and to address these challenges, we propose a rigorous retention plan and study management plan to track and follow-up with subjects enrolled at the UW Clinical Center. Continuing participation of the UW Clinical Center will significantly contribute to achieving LABS consortium stated aims:
Specific Aim 1 : Effectively retain subjects to complete the longitudinal, observational cohort database.
Specific Aim 2 : Complete the comprehensive LABS database and disseminate the LABS results to the medical and scientific communities.
Specific Aim 3 : Examine serial changes in biological outcomes (i.e. C-reactive protein, creatinine) in relation to weight loss and change in comorbidities.
Specific Aim 4 : Maintain the infrastructure to support the conduct and analysis of ancillary studies funded through external mechanisms.

Public Health Relevance

The LABS Consohtum is a well-developed research infrastructure that includes heterogeneous cohorts of bariatric surgery patients. Longer term follow-up will enable examination of the relationship between surgery and variable weight loss and regain of weight to clinical responses, the durability of the weight loss and the improvements in comorbidity responses, and examine post-surgical outcomes that evolve over time.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK066568-09
Application #
8317684
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Horlick, Mary
Project Start
2003-09-30
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$465,886
Indirect Cost
$100,954
Name
University of Washington
Department
Surgery
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Mitchell, James E; King, Wendy C; Courcoulas, Anita et al. (2015) Eating behavior and eating disorders in adults before bariatric surgery. Int J Eat Disord 48:215-22
Purnell, Jonathan Q; Selzer, Faith; Smith, Mark D et al. (2014) Metabolic syndrome prevalence and associations in a bariatric surgery cohort from the Longitudinal Assessment of Bariatric Surgery-2 study. Metab Syndr Relat Disord 12:86-94
Mitchell, James E; King, Wendy C; Chen, Jia-Yuh et al. (2014) Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study. Obesity (Silver Spring) 22:1799-806
Kleiner, David E; Berk, Paul D; Hsu, Jesse Y et al. (2014) Hepatic pathology among patients without known liver disease undergoing bariatric surgery: observations and a perspective from the longitudinal assessment of bariatric surgery (LABS) study. Semin Liver Dis 34:98-107
Cummings, David E; Cohen, Ricardo V (2014) Beyond BMI: the need for new guidelines governing the use of bariatric and metabolic surgery. Lancet Diabetes Endocrinol 2:175-81
Christian, Nicholas J; King, Wendy C; Yanovski, Susan Z et al. (2013) Validity of self-reported weights following bariatric surgery. JAMA 310:2454-6
King, Wendy C; Kalarchian, Melissa A; Steffen, Kristine J et al. (2013) Associations between physical activity and mental health among bariatric surgical candidates. J Psychosom Res 74:161-9
Gourash, William F; Ebel, Faith; Lancaster, Kathy et al. (2013) Longitudinal Assessment of Bariatric Surgery (LABS): retention strategy and results at 24 months. Surg Obes Relat Dis 9:514-9
Khan, Akram; King, Wendy C; Patterson, Emma J et al. (2013) Assessment of obstructive sleep apnea in adults undergoing bariatric surgery in the longitudinal assessment of bariatric surgery-2 (LABS-2) study. J Clin Sleep Med 9:21-9
Courcoulas, Anita P; Christian, Nicholas J; Belle, Steven H et al. (2013) Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA 310:2416-25

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