The University of Washington (UW) Clinical Center has been a significant contributor in the LABS Consortium since its inception and currently recruits subjects for LABS2 study from two Seattle-area hospitals performing bariatric operations: the University of Washington Medical Center (UWMC) and Virginia Mason Medical Center (VMMC). We propose to complete LABS2 recruitment at the UW Clinical Center by 6/30/2009 and to extend longitudinal follow-up of the LABS2 cohort through 6/30/2014. As the second highest Clinical Center contributor to LABS2 surgeries, we anticipate follow-up of 520 LABS2 subjects annually. An observational, longitudinal study innately involves retention challenges and to address these challenges, we propose a rigorous retention plan and study management plan to track and follow-up with subjects enrolled at the UW Clinical Center. Continuing participation of the UW Clinical Center will significantly contribute to achieving LABS consortium stated aims:
Specific Aim 1 : Effectively retain subjects to complete the longitudinal, observational cohort database.
Specific Aim 2 : Complete the comprehensive LABS database and disseminate the LABS results to the medical and scientific communities.
Specific Aim 3 : Examine serial changes in biological outcomes (i.e. C-reactive protein, creatinine) in relation to weight loss and change in comorbidities.
Specific Aim 4 : Maintain the infrastructure to support the conduct and analysis of ancillary studies funded through external mechanisms.

Public Health Relevance

The LABS Consohtum is a well-developed research infrastructure that includes heterogeneous cohorts of bariatric surgery patients. Longer term follow-up will enable examination of the relationship between surgery and variable weight loss and regain of weight to clinical responses, the durability of the weight loss and the improvements in comorbidity responses, and examine post-surgical outcomes that evolve over time.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK066568-10
Application #
8520289
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Horlick, Mary
Project Start
2003-09-30
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$490,597
Indirect Cost
$97,067
Name
University of Washington
Department
Surgery
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Purnell, Jonathan Q; Johnson, Geoffrey S; Wahed, Abdus S et al. (2018) Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. Diabetologia 61:1142-1154
King, Wendy C; Hinerman, Amanda S; Belle, Steven H et al. (2018) Comparison of the Performance of Common Measures of Weight Regain After Bariatric Surgery for Association With Clinical Outcomes. JAMA 320:1560-1569
Friedman, Allon N; Wahed, Abdus S; Wang, Junyao et al. (2018) Effect of Bariatric Surgery on CKD Risk. J Am Soc Nephrol 29:1289-1300
Courcoulas, Anita P; King, Wendy C; Belle, Steven H et al. (2018) Seven-Year Weight Trajectories and Health Outcomes in the Longitudinal Assessment of Bariatric Surgery (LABS) Study. JAMA Surg 153:427-434
Field, Alison E; Inge, Thomas H; Belle, Steven H et al. (2018) Association of Obesity Subtypes in the Longitudinal Assessment of Bariatric Surgery Study and 3-Year Postoperative Weight Change. Obesity (Silver Spring) 26:1931-1937
O'Rourke, Robert W; Johnson, Geoffrey S; Purnell, Jonathan Q et al. (2018) Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes. Int J Obes (Lond) :
Menke, Marie N; King, Wendy C; White, Gretchen E et al. (2017) Contraception and Conception After Bariatric Surgery. Obstet Gynecol 130:979-987
King, Wendy C; Chen, Jia-Yuh; Courcoulas, Anita P et al. (2017) Alcohol and other substance use after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1392-1402
King, Wendy C; Chen, Jia-Yuh; Belle, Steven H et al. (2017) Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1337-1346
Alfonso-Cristancho, Rafael; King, Wendy C; Mitchell, James E et al. (2016) Longitudinal Evaluation of Work Status and Productivity After Bariatric Surgery. JAMA 316:1595-1597

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