The study of bariatric surgery offers unique opportunities to evaluate the effects of weight loss among very obese individuals and how this influences quality of life, including impact on co-morbidities of obesity. This proposal is submitted as a collaborative effort of the Department of Medicine, Obesity and Nutrition Research Center (ONRC) and the Department of Epidemiology Prevention Center and Preventive Cardiology Program. We believe that the future studies of bariatric surgery have three important components. First, what is the long term outcome of bariatric surgery in terms of quality of life, morbidity and mortality and are there differences in outcome by type of surgery and characteristics of individuals having the surgery, especially in relationship to distribution of body weight and insulin resistance (IR). The most important health risks for obese individuals are related to cardiovascular disease (CVD). Obesity has been reported to be an independent risk factor for congestive heart failure (CHF) and also for hypertension, type 2 diabetes mellitus, and their complications. Second, the study of bariatric patients offers a unique opportunity to study the metabolic changes associated with obesity and weight loss especially in relationship to carbohydrate and fat metabolism. Third, it is important to try and determine the reasons why many patients can successfully maintain substantial weight loss with minimal co-morbidity after bariatric surgery and especially the potential importance of gastrointestinal physiology and CNS effects on maintaining long-term weight loss. The University of Pittsburgh Bariatric Surgery Program is one of the largest and most successful in the United States. We have excellent follow up of participants and have developed a major collaborative program within the University of Pittsburgh and other institutions. The ONRC is a major National Institutes of Health (NIH)-funded research program dedicated to the study of the pathophysiology of obesity and diabetes and to behavioral research both related to enhancing weight loss and exercise and studying the long term behavioral aspects of these interventions. The Cardiovascular Epidemiology Program in the Department of Epidemiology has extensive experience in observational and clinical trials with a special interest in the measurement of vascular disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK066585-05
Application #
7285958
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (O1))
Program Officer
Miles, Carolyn
Project Start
2003-09-30
Project End
2009-06-30
Budget Start
2007-09-01
Budget End
2009-06-30
Support Year
5
Fiscal Year
2007
Total Cost
$514,462
Indirect Cost
Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Field, Alison E; Inge, Thomas H; Belle, Steven H et al. (2018) Association of Obesity Subtypes in the Longitudinal Assessment of Bariatric Surgery Study and 3-Year Postoperative Weight Change. Obesity (Silver Spring) 26:1931-1937
O'Rourke, Robert W; Johnson, Geoffrey S; Purnell, Jonathan Q et al. (2018) Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes. Int J Obes (Lond) :
Purnell, Jonathan Q; Johnson, Geoffrey S; Wahed, Abdus S et al. (2018) Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. Diabetologia 61:1142-1154
King, Wendy C; Hinerman, Amanda S; Belle, Steven H et al. (2018) Comparison of the Performance of Common Measures of Weight Regain After Bariatric Surgery for Association With Clinical Outcomes. JAMA 320:1560-1569
Friedman, Allon N; Wahed, Abdus S; Wang, Junyao et al. (2018) Effect of Bariatric Surgery on CKD Risk. J Am Soc Nephrol 29:1289-1300
Menke, Marie N; King, Wendy C; White, Gretchen E et al. (2017) Contraception and Conception After Bariatric Surgery. Obstet Gynecol 130:979-987
King, Wendy C; Chen, Jia-Yuh; Courcoulas, Anita P et al. (2017) Alcohol and other substance use after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1392-1402
King, Wendy C; Chen, Jia-Yuh; Belle, Steven H et al. (2017) Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis 13:1337-1346
Kalarchian, Melissa A; King, Wendy C; Devlin, Michael J et al. (2016) Psychiatric Disorders and Weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up. Psychosom Med 78:373-81
Alfonso-Cristancho, Rafael; King, Wendy C; Mitchell, James E et al. (2016) Longitudinal Evaluation of Work Status and Productivity After Bariatric Surgery. JAMA 316:1595-1597

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