Our understanding of (UCPPS) such as interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome, (CP/CPPS) is poor. The objective of our proposal is to investigate the etiology, pathophysiology, and epidemiology of UCPPS in a multi-disciplinary manner. We have assembled a team of investigators from Washington University In St. Louis, the University of Alabama at Birmingham, the University of Miami, and the University of Texas at Dallas Southwestern Medical School, that consists of researchers from several disciplines: anesthesiology, rheumatology, gastroenterology, neuroradiology, molecular microbiology, infectious disease, epidemiology, psychology, and urology. By bringing together these successful and productive investigators with strong record of participating in collaborative science from disciplines outside of urology, many of them new to UCPPS research, we hope to introduce new expertise, test new hypotheses, and provide new direction to UCPPS research. A total of 5 projects are proposed to achieve our objective. Projects 1 and 2 will investigate the epidemiology of IC/PBS and CP/CPPS, respectively. In PROJECT 1, Drs Hooton and Hultgren will evaluate the role of bacteriuria, viruria, and infectious agents as an underlying etiology for IC/PBS in a prospective cohort study with frequent biologic specimen collection and daily patient-reported symptom diary. In PROJECT 2, Drs Colditz, Sutcliffe and Andriole will investigate the biologic and behavioral risk factors for development of CP/CPPS and symptom exacerbation using case-control studies and longitudinal studies. Projects 3, 4, and 5 share a common goal to evaluate the role of central nervous system abnormality in IC/PBS. In PROJECT 3, Drs Gereau and Lai will study the molecular mechanisms of spinal cord pain sensitization using an animal model that mimics IC pain. In PROJECT 4, Drs Ness, Bradley and Deutsch will use quantitative sensory testing (QST) and innovative intracerebral blood-flow neuroimaging techniques (CASL-fMRI) to evaluate sensory processing in IC/PBS patients with and without associated fibromyalgia. In PROJECT 5, Drs Hong and North will investigate the relationship between IC/PBS and somatization disorder. Collectively, we are confident that these 5 projects will address key questions in UCPPS research, and deepen our understanding of chronic pain syndromes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project--Cooperative Agreements (U01)
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Study Section
Special Emphasis Panel (ZDK1-GRB-G (M1))
Program Officer
Mullins, Christopher V
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Washington University
Schools of Medicine
Saint Louis
United States
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Clemens, J Quentin; Mullins, Chris; Kusek, John W et al. (2014) The MAPP research network: a novel study of urologic chronic pelvic pain syndromes. BMC Urol 14:57
Sutcliffe, Siobhan; Colditz, Graham A; Goodman, Melody S et al. (2014) Urological chronic pelvic pain syndrome symptom flares: characterisation of the full range of flares at two sites in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int 114:916-25
Landis, J Richard; Williams, David A; Lucia, M Scott et al. (2014) The MAPP research network: design, patient characterization and operations. BMC Urol 14:58
Kilpatrick, Lisa A; Kutch, Jason J; Tillisch, Kirsten et al. (2014) Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol 192:947-55
Stemler, Kristina M; Crock, Lara W; Lai, H Henry et al. (2013) Protamine sulfate induced bladder injury protects from distention induced bladder pain. J Urol 189:343-51
Lai, H Henry; North, Carol S; Andriole, Gerald L et al. (2012) Polysymptomatic, polysyndromic presentation of patients with urological chronic pelvic pain syndrome. J Urol 187:2106-12
Crock, Lara W; Stemler, Kristina M; Song, David G et al. (2012) Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Mol Pain 8:20
Lv, Haitao; Hung, Chia S; Chaturvedi, Kaveri S et al. (2011) Development of an integrated metabolomic profiling approach for infectious diseases research. Analyst 136:4752-63
Lv, Haitao; Henderson, Jeffrey P (2011) Yersinia high pathogenicity island genes modify the Escherichia coli primary metabolome independently of siderophore production. J Proteome Res 10:5547-54
Lai, H Henry; Qiu, Chang-Shen; Crock, Lara W et al. (2011) Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder. Pain 152:2117-24