Our understanding of (UCPPS) such as interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome, (CP/CPPS) is poor. The objective of our proposal is to investigate the etiology, pathophysiology, and epidemiology of UCPPS in a multi-disciplinary manner. We have assembled a team of investigators from Washington University In St. Louis, the University of Alabama at Birmingham, the University of Miami, and the University of Texas at Dallas Southwestern Medical School, that consists of researchers from several disciplines: anesthesiology, rheumatology, gastroenterology, neuroradiology, molecular microbiology, infectious disease, epidemiology, psychology, and urology. By bringing together these successful and productive investigators with strong record of participating in collaborative science from disciplines outside of urology, many of them new to UCPPS research, we hope to introduce new expertise, test new hypotheses, and provide new direction to UCPPS research. A total of 5 projects are proposed to achieve our objective. Projects 1 and 2 will investigate the epidemiology of IC/PBS and CP/CPPS, respectively. In PROJECT 1, Drs Hooton and Hultgren will evaluate the role of bacteriuria, viruria, and infectious agents as an underlying etiology for IC/PBS in a prospective cohort study with frequent biologic specimen collection and daily patient-reported symptom diary. In PROJECT 2, Drs Colditz, Sutcliffe and Andriole will investigate the biologic and behavioral risk factors for development of CP/CPPS and symptom exacerbation using case-control studies and longitudinal studies. Projects 3, 4, and 5 share a common goal to evaluate the role of central nervous system abnormality in IC/PBS. In PROJECT 3, Drs Gereau and Lai will study the molecular mechanisms of spinal cord pain sensitization using an animal model that mimics IC pain. In PROJECT 4, Drs Ness, Bradley and Deutsch will use quantitative sensory testing (QST) and innovative intracerebral blood-flow neuroimaging techniques (CASL-fMRI) to evaluate sensory processing in IC/PBS patients with and without associated fibromyalgia. In PROJECT 5, Drs Hong and North will investigate the relationship between IC/PBS and somatization disorder. Collectively, we are confident that these 5 projects will address key questions in UCPPS research, and deepen our understanding of chronic pain syndromes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M1))
Program Officer
Mullins, Christopher V
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Alger, Jeffry R; Ellingson, Benjamin M; Ashe-McNalley, Cody et al. (2016) Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network. Neuroimage Clin 12:65-77
Nickel, J Curtis; Stephens, Alisa; Landis, J Richard et al. (2016) Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol 195:356-62
Deutsch, Georg; Deshpande, Hrishikesh; Frölich, Michael A et al. (2016) Bladder Distension Increases Blood Flow in Pain Related Brain Structures in Subjects with Interstitial Cystitis. J Urol 196:902-10
Stephens-Shields, Alisa J; Clemens, J Quentin; Jemielita, Thomas et al. (2016) Symptom Variability and Early Symptom Regression in the MAPP Study: A Prospective Study of Urological Chronic Pelvic Pain Syndrome. J Urol 196:1450-1455
Huang, Lejian; Kutch, Jason J; Ellingson, Benjamin M et al. (2016) Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain 157:2782-2791
Griffith, James W; Stephens-Shields, Alisa J; Hou, Xiaoling et al. (2016) Pain and Urinary Symptoms Should Not be Combined into a Single Score: Psychometric Findings from the MAPP Research Network. J Urol 195:949-54
Naliboff, Bruce D; Stephens, Alisa J; Afari, Niloo et al. (2015) Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network. Urology 85:1319-27
Sutcliffe, Siobhan; Colditz, Graham A; Pakpahan, Ratna et al. (2015) Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: findings from one site of the MAPP Research Network. Neurourol Urodyn 34:188-95
Sutcliffe, Siobhan; Bradley, Catherine S; Clemens, James Quentin et al. (2015) Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network. Int Urogynecol J 26:1047-60
Martucci, Katherine T; Shirer, William R; Bagarinao, Epifanio et al. (2015) The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network. Pain 156:1755-64

Showing the most recent 10 out of 34 publications