Abstract

This study addresses the MAPP Research Network requirements for an epidemiological study and anexamination of the genetic contributions to one of the conditions termed 'urologic chronic pelvic painsyndromes' (UCPPS) by the MAPP initiative. Our objective in designing this project, and the University ofWashington (UW) Discovery Center as a wholejs to enhance the growing body of knowledge about UCPPS byusing a focused yet integrated multidisciplinary approach. Our approach will provide critical knowledge aboutthe underlying genetic and environmental factors that promote CP/CPPS and its primary symptom of pain. Onestrength of this project is its response to multiple Research Priorities outlined in the MAPP RFA. Our primaryaim is to determine the heritability of CP/CPPS by using genetic epidemiological strategies. A secondary aim isto address the phenotypic characteristics of CP/CPPS by examining current and historical demographic andpsychosocial characteristics, psychiatric symptoms, and functional status. By identifying a cohort of middleagedtwins with CP/CPPS, we also will set the stage for future projects that more comprehensively examinegenetic and physiological factors in this cohort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01DK082325-01
Application #
7570947
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M1))
Project Start
2008-09-15
Project End
2013-06-30
Budget Start
2008-09-15
Budget End
2009-06-30
Support Year
1
Fiscal Year
2008
Total Cost
$103,498
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Sutcliffe, Siobhan; Jemielita, Thomas; Lai, H Henry et al. (2018) A Case-Crossover Study of Urological Chronic Pelvic Pain Syndrome Flare Triggers in the MAPP Research Network. J Urol 199:1245-1251
Yang, Claire C; Miller, Jane L; Omidpanah, Adam et al. (2018) Physical Examination for Men and Women With Urologic Chronic Pelvic Pain Syndrome: A MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain) Network Study. Urology 116:23-29
Clemens, J Quentin; Stephens-Shields, Alisa; Naliboff, Bruce D et al. (2018) Correlates of Health Care Seeking Activities in Patients with Urological Chronic Pelvic Pain Syndromes: Findings from the MAPP Cohort. J Urol 200:136-140
Schrepf, Andrew; Naliboff, Bruce; Williams, David A et al. (2018) Adverse Childhood Experiences and Symptoms of Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med 52:865-877
Naliboff, Bruce D; Stephens, Alisa J; Lai, H Henry et al. (2017) Clinical and Psychosocial Predictors of Urological Chronic Pelvic Pain Symptom Change in 1 Year: A Prospective Study from the MAPP Research Network. J Urol 198:848-857
Kutch, Jason J; Labus, Jennifer S; Harris, Richard E et al. (2017) Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain 158:1069-1082
Kutch, Jason J; Ichesco, Eric; Hampson, Johnson P et al. (2017) Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain 158:1979-1991
Godfrey, Kathryn M; Herbert, Matthew; Strachan, Eric et al. (2017) Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female Twins. Clin J Pain 33:246-253
Gasperi, Marianna; Krieger, John N; Forsberg, Christopher et al. (2017) Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study. J Psychosom Res 102:29-33
Lai, H Henry; Jemielita, Thomas; Sutcliffe, Siobhan et al. (2017) Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study. J Urol 198:622-631

Showing the most recent 10 out of 49 publications