This proposal responds to RFA of -DK-07-003, which requests applications for Discovery Centers to collaborate with other Discovery Centers in a Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. In this application, the University of Washington (UW) seeks support for a Discovery Center to participate in efforts to unravel the enigma of what has been termed urologic chronic pelvic pain syndromes (UCPPS) by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This proposal was developed following the guidelines stipulated by the NIDDK for Program Project Grants and Cooperative Agreements.
The aims of these Discovery Centers, in conjunction with the Tissue Analysis and Technology Core and the Data Coordination Core, are to conduct multi-disciplinary, multi-site, basic, translational, and clinical research in the field of UCPPS. The goals of the MAPP Research Network are to 1) identify UCPPS disease phenotypes;2) determine how UCPPS fit into the larger spectrum of related chronic pain syndromes (RCPS);3) conduct targeted epidemiological studies of UCPPS using relevant patient populations;and 4) use basic cellular, molecular, and biochemical techniques to examine the pathophysiology of UCPPS. More broadly, each site will need to collaborate closely with NIDDK staff and other Network Centers to complete multidisciplinary, multi-site, and highly interactive studies, and to obtain specimens for basic science studies. In addition, Discovery Centers will need the flexibility to accept and implement new and perhaps unconventional UCPPS definitions, and to both import and export study designs and methods pertinent to UCPPS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK082325-04
Application #
8137281
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M1))
Program Officer
Mullins, Christopher V
Project Start
2008-09-15
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
4
Fiscal Year
2011
Total Cost
$965,438
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Naliboff, Bruce D; Stephens, Alisa J; Lai, H Henry et al. (2017) Clinical and Psychosocial Predictors of Urological Chronic Pelvic Pain Symptom Change in 1 Year: A Prospective Study from the MAPP Research Network. J Urol 198:848-857
Godfrey, Kathryn M; Herbert, Matthew; Strachan, Eric et al. (2017) Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female Twins. Clin J Pain 33:246-253
Lai, H Henry; Jemielita, Thomas; Sutcliffe, Siobhan et al. (2017) Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study. J Urol 198:622-631
Gasperi, Marianna; Krieger, John N; Forsberg, Christopher et al. (2017) Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study. J Psychosom Res 102:29-33
Kutch, Jason J; Labus, Jennifer S; Harris, Richard E et al. (2017) Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain 158:1069-1082
Alger, Jeffry R; Ellingson, Benjamin M; Ashe-McNalley, Cody et al. (2016) Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network. Neuroimage Clin 12:65-77
Huang, Lejian; Kutch, Jason J; Ellingson, Benjamin M et al. (2016) Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain 157:2782-2791
Kleinhans, Natalia M; Yang, Claire C; Strachan, Eric D et al. (2016) Alterations in Connectivity on Functional Magnetic Resonance Imaging with Provocation of Lower Urinary Tract Symptoms: A MAPP Research Network Feasibility Study of Urological Chronic Pelvic Pain Syndromes. J Urol 195:639-45
Afari, Niloofar; Gasperi, Marianna; Forsberg, Christopher W et al. (2016) Heritability of Lower Urinary Tract Symptoms in Men: A Twin Study. J Urol 196:1486-1492
Nickel, J Curtis; Stephens, Alisa; Landis, J Richard et al. (2016) Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol 195:356-62

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