Our central hypothesis in the Michigan MAPP Discovery Site is that a subset of women with IC/PBS have a """"""""central"""""""" neurobiological problem in pain or sensory processing, as occurs in fibromyalgia (FM), rather than a disorder confined to the bladder. Project 2, Pain and Sensory Processing in IC/PBS and Fibromyalgia, will be co-led by Drs. David Williams and Richard Gracely. This study will perform experimental sensory testing and functional neuroimaging in women with IC/PBS, and compare these results to matched a) healthy female controls, and b) female FM patients. We hypothesize that these studies will show that IC/PBS patients are diffusely sensitive to pain and other sensory stimuli, similar to FM patients, and different from controls.
The specific aims of this study are: 1) Tp characterize IC/PBS patients regarding the presence of signs and symptoms of FM, irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), and related conditions, and verify a high rate of co-morbid syndromes, 2) To show that individuals with IC/PBS are tender throughout their body, similar to fibromyalgia patients, and different from controls, 3) To show that IC/PBS patients, like FM patients, are also more sensitive to the loudness of auditory tones, even when these are presented in a manner that minimizes or eliminates response bias, and 4) To demonstrate that this """"""""leftshift"""""""" in stimulus response function in IC/PBS is not only identified using self-report measures, but also present when functional MRI (fMRI) is used to assess the augmented neuronal response to painful pressure stimuli and auditory tones. Establishing that 1C patients display augmented central pain and sensory processing, like other conditions such as FM and IBS, will greatly advance this field, by making useful a variety of functional neuroimaging and other research methods that can be used to study central neurobiological mechanisms in these chronic pelvic pain syndromes. Similarly, showing similarities amongst these disorders would logically lead to testing therapies in IC/PBS patients that are found to be efficacious in fibromyalgia and related conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK082345-03
Application #
8141423
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
3
Fiscal Year
2010
Total Cost
$328,680
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sutcliffe, Siobhan; Jemielita, Thomas; Lai, H Henry et al. (2018) A Case-Crossover Study of Urological Chronic Pelvic Pain Syndrome Flare Triggers in the MAPP Research Network. J Urol 199:1245-1251
Harper, Daniel E; Ichesco, Eric; Schrepf, Andrew et al. (2018) Relationships between brain metabolite levels, functional connectivity, and negative mood in urologic chronic pelvic pain syndrome patients compared to controls: A MAPP research network study. Neuroimage Clin 17:570-578
Clemens, J Quentin; Stephens-Shields, Alisa; Naliboff, Bruce D et al. (2018) Correlates of Health Care Seeking Activities in Patients with Urological Chronic Pelvic Pain Syndromes: Findings from the MAPP Cohort. J Urol 200:136-140
Schrepf, Andrew; Naliboff, Bruce; Williams, David A et al. (2018) Adverse Childhood Experiences and Symptoms of Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med 52:865-877
Naliboff, Bruce D; Stephens, Alisa J; Lai, H Henry et al. (2017) Clinical and Psychosocial Predictors of Urological Chronic Pelvic Pain Symptom Change in 1 Year: A Prospective Study from the MAPP Research Network. J Urol 198:848-857
Kutch, Jason J; Labus, Jennifer S; Harris, Richard E et al. (2017) Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain 158:1069-1082
Kutch, Jason J; Ichesco, Eric; Hampson, Johnson P et al. (2017) Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain 158:1979-1991
Lai, H Henry; Jemielita, Thomas; Sutcliffe, Siobhan et al. (2017) Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study. J Urol 198:622-631
Dagher, Adelle; Curatolo, Adam; Sachdev, Monisha et al. (2017) Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int 120:130-142
Nickel, J Curtis; Stephens, Alisa; Landis, J Richard et al. (2016) Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol 195:356-62

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