Lower urinary tract dysfunction (LUTD) is common, and its incidence and prevalence are increasing as the population ages. Symptoms of LUTD are costly to diagnose and treat;existing therapeutic interventions are neither highly effective nor durable and have side effects of their own. Not surprisingly, unsatisfactory outcomes from the patient perspective are common. Collectively, these challenges represent important targets of research that are consistent with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Previous efforts to improve patient reported outcomes (PRO) in this area have relied on incomplete symptom measurement scales and have been hampered by imperfect understanding of the origin and natural history of LUTD. Comprehensive re-evaluation of the symptom universe of LUTD and more precise characterization of patients with symptoms of LUTD (phenotyping) may provide significant new insights, leading ultimately to improved patient lives. The NIDDK-sponsored Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) includes a Data Coordinating Center (DCC) to serve as the project and data management nexus for the network. The purpose of this project is to expand the DCC, and increase the number of clinical sites that will enroll patients with symptoms of LUTD into carefully designed studies. There are three specific aims. The first is to expand the infrastructure of the LURN network to accommodate the addition of three to four clinical sites, plus the anticipated increase in complexity in supporting a larger consortium. The second specific aim is to enhance the collaboration between stakeholders by increasing the number of face-to-face meetings of the Steering Committee from one (currently) to three annually.
The third aim i s to expand the LURN consortium's patient-reported outcome measurement tools to include development and implementation of computerized adaptive testing.

Public Health Relevance

The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) will study people who have symptoms of lower urinary tract dysfunction (LUTD). The scientific collaborators will ask patients to participate in studies that will include he development of surveys to help patients to better explain their symptoms and to communicate how much those symptoms affect their lives. The scientists will also develop symptom profiles that will help doctors better diagnose and treat the symptoms of LUTD. Finally, the researchers will try to determine whether there are substances in blood or urine that can help improve our understanding of these symptoms and the diseases that cause them.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01DK099879-01
Application #
8585774
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M5))
Program Officer
Kirkali, Ziya
Project Start
2013-07-25
Project End
2018-05-31
Budget Start
2013-07-25
Budget End
2014-05-31
Support Year
1
Fiscal Year
2013
Total Cost
$489,621
Indirect Cost
$107,999
Name
Arbor Research Collaborative for Health
Department
Type
DUNS #
364217265
City
Ann Arbor
State
MI
Country
United States
Zip Code
48104