This proposal responds to RFA-DK-12-017, which requests applications for Research Sites to collaborate with existing Research Sites in the Lower Urinary Tract Dysfunction Research Network (LURN). In this application, the University of Washington (UW) seeks support for a Research Site to participate in efforts to unravel the clinically confounding symptoms of the lower urinary tract. This proposal was developed following the guidelines stipulated by the National Institute of Diabetes, Digestive and Kidney diseases (NIDDK).
The aim of the proposed UW Research Site, in conjunction with the Data Coordination Center and existing LURN Research Sites, is to expand on validating symptom-based instruments to measure early, late, transient, and persistent symptoms both in males and females, and to better define the phenotypes of men and women with symptoms of lower urinary tract dysfunction. The key responsibilities of the Research Site will be to adopt the study protocols developed by the LURN investigators, validate the developed Patient Reported Outcome (PRO) measures, recruit study participants, and conduct extensive characterization (phenotyping) of them.

Public Health Relevance

The aim of the proposed UW Research Site, in conjunction with the Data Coordination Center and existing LURN Research Sites, is to validate symptom-based instruments to measure early, late, transient, and persistent urinary symptoms both in males and females, and to better define the phenotypes of men and women with symptoms of lower urinary tract dysfunction. The relevance of the project Is to identify subgroups of persons with urinary symptoms, in order to find the causes of the symptoms and identify better treatment regimens.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK100011-02
Application #
8700401
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M5))
Program Officer
Kirkali, Ziya
Project Start
2013-07-15
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$476,690
Indirect Cost
$147,693
Name
University of Washington
Department
Urology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Helfand, Brian T; Smith, Abigail R; Lai, H Henry et al. (2018) Prevalence and Characteristics of Urinary Incontinence in a Treatment Seeking Male Prospective Cohort: Results from the LURN Study. J Urol 200:397-404
Andreev, Victor P; Liu, Gang; Yang, Claire C et al. (2018) Symptom Based Clustering of Women in the LURN Observational Cohort Study. J Urol 200:1323-1331
Cameron, Anne P; Lewicky-Gaupp, Christina; Smith, Abigail R et al. (2018) Baseline Lower Urinary Tract Symptoms in Patients Enrolled in LURN: A Prospective, Observational Cohort Study. J Urol 199:1023-1031
Griffith, James W; Messersmith, Emily E; Gillespie, Brenda W et al. (2018) Reasons for Seeking Clinical Care for Lower Urinary Tract Symptoms: A Mixed Methods Study. J Urol 199:528-535
Helmuth, Margaret E; Smith, Abigail R; Andreev, Victor P et al. (2018) Use of Euclidean length to measure urinary incontinence severity based on the lower urinary tract symptoms tool. Am J Obstet Gynecol 218:357-359
Lai, H Henry; Naliboff, Bruce; Liu, Alice B et al. (2018) The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations. Contemp Clin Trials 74:76-87
Siddiqui, Nazema Y; Wiseman, Jonathan B; Cella, David et al. (2018) Mental Health, Sleep and Physical Function in Treatment Seeking Women with Urinary Incontinence. J Urol 200:848-855
Cameron, Anne P; Smith, Abigail R; Lai, H Henry et al. (2018) Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence. Neurourol Urodyn 37:2586-2596
Bradley, Catherine S; Erickson, Bradley A; Messersmith, Emily E et al. (2017) Evidence of the Impact of Diet, Fluid Intake, Caffeine, Alcohol and Tobacco on Lower Urinary Tract Symptoms: A Systematic Review. J Urol 198:1010-1020
Yang, Claire C; Weinfurt, Kevin P; Merion, Robert M et al. (2016) Symptoms of Lower Urinary Tract Dysfunction Research Network. J Urol 196:146-52