The proposed coordinating center for the CKD Biomarkers Consortium (BioCon) will support scientific development and implementation of a broad array of research protocols conducted by Participating Centers and pilot grant awardees. The BioCon Scientific and Data Coordinating Center (SDCC) will enhance biomarker science in CKD by providing expertise and leadership in epidemiological study design, biostatistics, laboratory science, stewardship of biosample resources drawn from geographically dispersed sources, and the collaborative implementation of protocols conducted by the diverse members of the BioCon research network.
The specific aims of the BioCon SDCC include: 1) To enhance biomarker research in CKD by providing scientific and laboratory leadership and coordination in the design and implementation of research protocols across the CKD BioCon network, 2) To provide biostatistical expertise in research designs, outcome measures and to perform analyses for development, validation and qualification of biomarkers for CKD, 3) To provide comprehensive SDCC administrative and logistical support for CKD BioCon, promoting effective communications (within the Steering Committee, with NIDDK, with NIDDK's External Expert Panel), coordinating and supporting teleconferences, meetings, subcommittees, scientific reports, and document development and management, maintaining a website, and preparing standard and special reports of consortium activities, 4) To coordinate and track the transfer of data and biospecimens between members of the consortium and appropriate repositories, and to establish a comprehensive database of information from approved CKD BioCon protocols, 5) To promote network-wide quality assurance standards, practices and tools, and engage in quality control of biospecimen assays throughout the consortium, and 6) To develop, implement, and monitor a CKD BioCon Pilot and Feasibility Projects program, and to support the conduct of the pilot studies.

Public Health Relevance

The CKD Biomarkers Consortium will leverage stored biosamples from well-characterized patients with renal disease, including longitudinal follow up, to discover and validate traditional and novel biomarkers in people with chronic kidney disease. The proposed Scientific and Data Coordinating Center for the CKD Biomarkers Consortium (BioCon) will support scientific development and implementation of a broad array of research protocols conducted by Participating Centers and pilot grant awardees. The BioCon Scientific and Data Coordinating Center (SDCC) will enhance biomarker science in CKD by providing expertise and leadership in epidemiological study design, biostatistics, laboratory science, stewardship of biosample resources drawn from geographically dispersed sources, and the collaborative implementation of protocols conducted by the diverse members of the BioCon research network.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01DK103225-01
Application #
8775993
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Kimmel, Paul
Project Start
2014-09-18
Project End
2019-06-30
Budget Start
2014-09-18
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$2,000,000
Indirect Cost
$750,000
Name
University of Pennsylvania
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104