The PLUS Loyola Clinical Center (PLUS-LCC) is a well-organized, experienced, collaborative team that has been designed to robustly contribute to the goals of the PLUS network. With depth and breadth of research expertise, PLUS-LCC plans four, well- integrated studies that map onto an interdependent ecological level of LUTS influence and facilitate examination of within-study and cross-study consideration of risk and protective factors. The PLUS-LCC will optimize these valuable research cohorts through the use of an overlapping subsample of study participants and mixed-methodological approaches. In the proposed PLUS-LCC studies, we will explore the community, cultural context by engaging in a Chicago-wide participatory, mixed methodological community-based Pelvic Health Assessment by conducting the first Chicago LUTS and community health survey, first large scale qualitative study on community members pelvic health perceptions, behaviors and knowledge groups, and conduct landscape assessment to characterize Chicago's health care system where women interface. PLUS-LCC will also examine individual-level influences and behavior through the study of urinary microbiome variability and comparison of individual behaviors, assess musculoskeletal milleu in lower-and back pain to determine its association with LUTS; and investigate relationship-level influence to locate LUTS discussion patterns, vertically among generations and horizontally among peers. As a strong contributor for PLUS, the Loyola Clinical Center contributes expertise in study concept, design, conduct, analysis and dissemination. Our collaborative approach will help bring out the best in other PLUS investigators, as they will for us. The PLUS network has the opportunity to make advances in the long understudied role of LUTS prevention.

Public Health Relevance

The Loyola Clinical Center contributes research depth and breadth to the PLUS network, with interdisciplinary collaborative research teams in the Female Urinary Microbiome, Community-based Participatory Action and Social Network Analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK106898-04
Application #
9534605
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kirkali, Ziya
Project Start
2015-08-20
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Loyola University Chicago
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153