The investigators have invented a very simple, but extremely powerful, new technology for detection and identification of volatile organic compounds (VOCs): colorimetric sensor arrays. These are inexpensive, disposable sensor arrays based on equilibrium interactions of analytes with metalloporphyrins and other chemically responsive dyes. As with human olfaction, our colorimetric sensor arrays use a large number of cross-reactive sensors that probe a wide range of chemical properties. By digitally monitoring the change in color of each dye in the array, they have a quantitative measure of a composite response to volatile organics. Chemometric pattern recognition is extremely powerful with these arrays because of their very high dimensionality. the investigators are now extending this work to biomedical applications, with specific aims focusing on the development of a personal chemical dosimeter for the detection, identification, and quantification of environmental/workplace VOCs. The sensitivity of the arrays permits rapid detection of very low levels of most volatile toxicants. This is a translational technology that should find substantial use in workplace monitoring of chemical exposure. Their efforts in these areas should lead (1) to fundamental advances in sensor development for molecular recognition and biomedical applications of such sensor arrays, (2) development and refinement of technology for the rapid and continuous identification and quantitation of volatile chemical toxicants, and most importantly, (3) prototyping of an extremely portable device for the assessment of personal VOC exposure;this device will provide continuous, quantitative, reliable, reproducible, multiplexed measurement of environmental exposures with rapid response (i.e., seconds) that requires essentially no user intervention for field deployment and data capture. This self-contained, easy-to-use device will prove ideal for multi-analyte measurement of point-of-contact exposures to priority environmental chemicals for use within future population-based biomedical studies of diverse populations. The device will be able to measure analyte concentrations continuously, will require essentially no user intervention for field deployment and data capture, and will be capable of real-time telemetry to a centralized system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01ES016011-04
Application #
7849637
Study Section
Special Emphasis Panel (ZES1-RAM-D (U1))
Program Officer
Balshaw, David M
Project Start
2007-08-15
Project End
2013-05-31
Budget Start
2010-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2010
Total Cost
$614,068
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Zhong, Wenxuan; Suslick, Kenneth S (2015) MATRIX DISCRIMINANT ANALYSIS WITH APPLICATION TO COLORIMETRIC SENSOR ARRAY DATA. Technometrics 57:524-534
Zhang, Yinan; Askim, Jon R; Zhong, Wenxuan et al. (2014) Identification of pathogenic fungi with an optoelectronic nose. Analyst 139:1922-8
Askim, Jon R; Mahmoudi, Morteza; Suslick, Kenneth S (2013) Optical sensor arrays for chemical sensing: the optoelectronic nose. Chem Soc Rev 42:8649-82
Suslick, Kenneth S (2012) Synesthesia in science and technology: more than making the unseen visible. Curr Opin Chem Biol 16:557-63
Mazzone, Peter J; Wang, Xiao-Feng; Xu, Yaomin et al. (2012) Exhaled breath analysis with a colorimetric sensor array for the identification and characterization of lung cancer. J Thorac Oncol 7:137-42
Carey, James R; Suslick, Kenneth S; Hulkower, Keren I et al. (2011) Rapid identification of bacteria with a disposable colorimetric sensing array. J Am Chem Soc 133:7571-6
Lin, Hengwei; Jang, Minseok; Suslick, Kenneth S (2011) Preoxidation for colorimetric sensor array detection of VOCs. J Am Chem Soc 133:16786-9
Kemling, Jonathan W; Qavi, Abraham J; Bailey, Ryan C et al. (2011) Nanostructured Substrates for Optical Sensing. J Phys Chem Lett 2:2934-2944
Kemling, Jonathan W; Suslick, Kenneth S (2011) Nanoscale porosity in pigments for chemical sensing. Nanoscale 3:1971-3
Feng, Liang; Musto, Christopher J; Kemling, Jonathan W et al. (2010) Colorimetric sensor array for determination and identification of toxic industrial chemicals. Anal Chem 82:9433-40

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