The CYGNET Study (Cohort study of Young Girls'Nutrition, Environment, and Transitions) is a prospective cohort study of 444 girls that is examining environmental, lifestyle, and genetic factors in the development of early puberty and other hallmarks of maturation. Participants were aged 6-8 years at the time of enrollment from June 2005 to August 2006, and the investigators are currently in their 5th annual (4th follow-up) exam cycle. The study rationale lies in the growing recognition that the pubertal transition may be an important window of susceptibility in establishing long-term risk of breast cancer. The potential exposures to chemicals that are hormonally active raise concerns that these exposures and other lifestyle and genetic factors may play important roles in modifying age-at-onset of puberty and other hallmarks of sexual maturation. This cohort study is thus focused on determining factors that are associated with various milestones in sexual maturation. A key focus has been on breast development, as assessed by Tanner stage at annual clinical exams. As they continue to follow study participants, other parameters that may be associated with breast cancer risk are of interest, including onset of menses, establishment of cycle regularity, tempo (the time from onset of puberty to onset of menses), peak height velocity, and attainment of adult height. Exposures of interest are assessed through clinical exam (e.g., anthropometry), interviews and questionnaires (e.g., personal care product use, physical activity, food intake, psychosocial factors), and collection and assay of biospecimens (urine, blood, saliva) for environmental and genetic factors. Interactions with study participants and the broader community are facilitated by close integration with community partners, who are also involved in all aspects of study protocol. Through the 4th annual exam cycle, the investigators collected data from 391 (88%) of the original cohort of 444 girls. After the 1st follow-up year, they have retained annually over 97% of the cohort. Assuming similar annual retention rates, they estimate that for the ninth exam cycle in 2013-2014 when girls are 14-16 years old, we will see approximately 339 girls. By then, we expect that all girls will have begun puberty, most will have experienced peak height velocity and onset of menarche, and a small number will have achieved their adult height. Using conservative assumptions, the investigators should have adequate power to detect associations for most major endpoints of about 1.57 comparing high and low quartiles of a continuous variable such as biomarker levels. The investigators anticipate continuing our collaborations with similar studies in Cincinnati and New York.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01ES019435-05S1
Application #
8914079
Study Section
Special Emphasis Panel (ZES1-LKB-V (02))
Program Officer
Dilworth, Caroline H
Project Start
2010-09-03
Project End
2015-04-30
Budget Start
2014-08-19
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$47,305
Indirect Cost
$2,037
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Windham, Gayle C; Lum, Raymond; Voss, Robert et al. (2017) Age at Pubertal Onset in Girls and Tobacco Smoke Exposure During Pre- and Postnatal Susceptibility Windows. Epidemiology 28:719-727
Sheffield, Perry E; Uijttewaal, Simone A M; Stewart, James et al. (2017) Climate Change and Schools: Environmental Hazards and Resiliency. Int J Environ Res Public Health 14:
Wolff, Mary S; Pajak, Ashley; Pinney, Susan M et al. (2017) Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls. Reprod Toxicol 67:56-64
Hiatt, Robert A; Stewart, Susan L; Hoeft, Kristin S et al. (2017) Childhood Socioeconomic Position and Pubertal Onset in a Cohort of Multiethnic Girls: Implications for Breast Cancer. Cancer Epidemiol Biomarkers Prev 26:1714-1721
Mervish, Nancy A; Teitelbaum, Susan L; Pajak, Ashley et al. (2017) Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls. Pediatr Res 82:201-208
Deierlein, Andrea L; Wolff, Mary S; Pajak, Ashley et al. (2017) Phenol Concentrations During Childhood and Subsequent Measures of Adiposity Among Young Girls. Am J Epidemiol 186:581-592
Deierlein, Andrea L; Wolff, Mary S; Pajak, Ashley et al. (2016) Longitudinal Associations of Phthalate Exposures During Childhood and Body Size Measurements in Young Girls. Epidemiology 27:492-9
Gonzales, Felisa A; Jones, Rena R; Deardorff, Julianna et al. (2016) Neighborhood deprivation, race/ethnicity, and urinary metal concentrations among young girls in California. Environ Int 91:29-39
Wilken, Jason A; Greenspan, Louise C; Kushi, Lawrence H et al. (2016) Thyroid Hormones and Timing of Pubertal Onset in a Longitudinal Cohort of Females, Northern California, 2006-11. Paediatr Perinat Epidemiol 30:285-93
McGuinn, Laura A; Voss, Robert W; Laurent, Cecile A et al. (2016) Residential proximity to traffic and female pubertal development. Environ Int 94:635-641

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