The National Institute for Environmental Health Sciences and the National Cancer Institute propose to continue support for studies of the environmental impact on the etiology of breast cancer, especially through understanding the role of the environment on puberty and early development. As part of this initiative, the Breast Cancer and the Environment Program (BCERP), they will support the continuation of a cohort of young girls through puberty and into adolescence to assess a broad range of environmental factors on pubertal outcomes and intermediate markers of breast cancer risk. The investigators herein propose to be the Coordinating Center for the BCERP.
Their specific aims will be: 1) To act as a central repository and clearinghouse for cross-site data from the epidemiologic study of girls early development through puberty and into adolescence;be responsible for the entry, coordination, monitoring, and harmonization of all data collected for cross-site analysis, basic analytic support and facilitation of data sharing and cross-site activities;. 2) To organize meetings and regular conference calls for all organizational entities within the BCERP, including annual business and scientific meetings and meetings to promote transdisciplinary science and other functions required of the BCERP;3) To facilitate the monthly meetings and other activities of the BCERP Steering Committee; 4) To compile for the Steering Committee regular reports of research activities and accomplishments of the epidemiologic studies;facilitate the NIH oversight and administration of the BCERP and the Pilot Project/Opportunity Fund;and, 5) To support the operations of an expert Working Group on Breast Cancer and the Environment. The investigators believe that they have several significant strengths to be considered in this application, which include;highly experienced and relevant leadership;the highly experienced and well established San Francisco Coordinating Center at the University of California San Francisco (UCSF);and an organizational structure that takes advantage of their past experience of seven years in the Breast Cancer and the Environment Research Centers, which was the first phase of this research initiative.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01ES019457-04
Application #
8464570
Study Section
Special Emphasis Panel (ZES1-LKB-V (02))
Program Officer
Dilworth, Caroline H
Project Start
2010-09-01
Project End
2015-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$507,438
Indirect Cost
$114,326
Name
University of California San Francisco
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Gonzales, Felisa A; Jones, Rena R; Deardorff, Julianna et al. (2016) Neighborhood deprivation, race/ethnicity, and urinary metal concentrations among young girls in California. Environ Int 91:29-39
Wilken, Jason A; Greenspan, Louise C; Kushi, Lawrence H et al. (2016) Thyroid Hormones and Timing of Pubertal Onset in a Longitudinal Cohort of Females, Northern California, 2006-11. Paediatr Perinat Epidemiol 30:285-93
Kale, Aarti; Deardorff, Julianna; Lahiff, Maureen et al. (2015) Breastfeeding versus formula-feeding and girls' pubertal development. Matern Child Health J 19:519-27
Wolff, Mary S; Teitelbaum, Susan L; McGovern, Kathleen et al. (2015) Environmental phenols and pubertal development in girls. Environ Int 84:174-80
Hong, Chi-Chen; Pajak, Ashley; Teitelbaum, Susan L et al. (2014) Younger pubertal age is associated with allergy and other atopic conditions in girls. Pediatr Allergy Immunol 25:773-80
Hoyt, Lindsay T; Kushi, Lawrence H; Leung, Cindy W et al. (2014) Neighborhood influences on girls' obesity risk across the transition to adolescence. Pediatrics 134:942-9
Pinney, Susan M; Biro, Frank M; Windham, Gayle C et al. (2014) Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA. Environ Pollut 184:327-34
Vangeepuram, Nita; McGovern, Kathleen J; Teitelbaum, Susan et al. (2014) Asthma and physical activity in multiracial girls from three US sites. J Asthma 51:193-9
Stueve, Theresa Ryan; Wolff, Mary S; Pajak, Ashley et al. (2014) CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls. BMC Pediatr 14:78
Wolff, M S; Teitelbaum, S L; McGovern, K et al. (2014) Phthalate exposure and pubertal development in a longitudinal study of US girls. Hum Reprod 29:1558-66

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