Human exposure to Bisphenol A (BPA), found in polycarbonate plastics, epoxy resins, and carbonless thermal receipts, among other products, is nearly ubiquitous. Numerous studies by us and others in a range of species have shown that BPA exposure during critical windov /s of development alters sociosexual, mood, learning and memory-related behaviors raising concern that BPA exposure, particularly during gestation and early life, might be contributing to increased incidences of behavioral disorders in children and adults. Because most studies to date were not specifically designed to guide human risk assessment, leveraging the NTP/FDA chronic exposure study in Sprague Dawley rats to characterize how perinatal BPA exposure affects anxiety, memory-related, copulatory and mate preference behaviors during juvenile and adult life across three human-relevant doses will yield critical data that can inform public policy regarding the potential health effects of BPA. This proposed studies will test the hypothesis that BPA disrupts behavioral responses by altering sex specific developmental programming of the hippocampus and hypothalamus, potentially by altering the epigenetic landscape and subsequent gene expression. Worl

Public Health Relevance

Bisphenol A (BPA) is a high volume production chemical found in numerous household items from which it leaches including plastic containers, dental materials, and metallic can liners. We will examine as part ofthe NCTR/FDA study, whether early BPA exposure induces early molecular changes within the brain that lead to behavioral deficiencies, including increased anxiety and decreased memory in juveniles and adults.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-JAB-J (BP))
Program Officer
Heindel, Jerrold
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
North Carolina State University Raleigh
Schools of Earth Sciences/Natur
United States
Zip Code
Rosenfeld, Cheryl S; Javurek, Angela B; Johnson, Sarah A et al. (2018) Seminal fluid metabolome and epididymal changes after antibiotic treatment in mice. Reproduction 156:1-10
Arambula, Sheryl E; Jima, Dereje; Patisaul, Heather B (2018) Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study. Neurotoxicology 65:207-220
Prins, Gail S; Patisaul, Heather B; Belcher, Scott M et al. (2018) CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems. Basic Clin Pharmacol Toxicol :
Arambula, Sheryl E; Fuchs, Joelle; Cao, Jinyan et al. (2017) Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-BPA consortium study. Neurotoxicology 63:33-42
Rosenfeld, Cheryl S; Denslow, Nancy D; Orlando, Edward F et al. (2017) Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates. J Toxicol Environ Health B Crit Rev 20:276-304
Patisaul, Heather B (2017) Endocrine Disruption of Vasopressin Systems and Related Behaviors. Front Endocrinol (Lausanne) 8:134
Rebuli, Meghan E; Patisaul, Heather B (2016) Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain. J Steroid Biochem Mol Biol 160:148-59
Arambula, Sheryl E; Belcher, Scott M; Planchart, Antonio et al. (2016) Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study. Endocrinology 157:3856-3872
Johnson, Sarah A; Javurek, Angela B; Painter, Michele S et al. (2016) Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study. Horm Behav 80:139-148
Rebuli, Meghan E; Camacho, LuĂ­sa; Adonay, Maria E et al. (2015) Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study. Toxicol Sci 148:341-54

Showing the most recent 10 out of 11 publications