Human exposure to Bisphenol A (BPA), found in polycarbonate plastics, epoxy resins, and carbonless thermal receipts, among other products, is nearly ubiquitous. Numerous studies by us and others in a range of species have shown that BPA exposure during critical windov /s of development alters sociosexual, mood, learning and memory-related behaviors raising concern that BPA exposure, particularly during gestation and early life, might be contributing to increased incidences of behavioral disorders in children and adults. Because most studies to date were not specifically designed to guide human risk assessment, leveraging the NTP/FDA chronic exposure study in Sprague Dawley rats to characterize how perinatal BPA exposure affects anxiety, memory-related, copulatory and mate preference behaviors during juvenile and adult life across three human-relevant doses will yield critical data that can inform public policy regarding the potential health effects of BPA. This proposed studies will test the hypothesis that BPA disrupts behavioral responses by altering sex specific developmental programming of the hippocampus and hypothalamus, potentially by altering the epigenetic landscape and subsequent gene expression. Worl Bisphenol A (BPA) is a high volume production chemical found in numerous household items from which it leaches including plastic containers, dental materials, and metallic can liners. We will examine as part ofthe NCTR/FDA study, whether early BPA exposure induces early molecular changes within the brain that lead to behavioral deficiencies, including increased anxiety and decreased memory in juveniles and adults.
Public Health Relevance
Bisphenol A (BPA) is a high volume production chemical found in numerous household items from which it leaches including plastic containers, dental materials, and metallic can liners. We will examine as part ofthe NCTR/FDA study, whether early BPA exposure induces early molecular changes within the brain that lead to behavioral deficiencies, including increased anxiety and decreased memory in juveniles and adults.
|Arambula, Sheryl E; Jima, Dereje; Patisaul, Heather B (2017) Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study. Neurotoxicology :|
|Arambula, Sheryl E; Fuchs, Joelle; Cao, Jinyan et al. (2017) Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-BPA consortium study. Neurotoxicology 63:33-42|
|Rosenfeld, Cheryl S; Denslow, Nancy D; Orlando, Edward F et al. (2017) Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates. J Toxicol Environ Health B Crit Rev 20:276-304|
|Patisaul, Heather B (2017) Endocrine Disruption of Vasopressin Systems and Related Behaviors. Front Endocrinol (Lausanne) 8:134|
|Rebuli, Meghan E; Patisaul, Heather B (2016) Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain. J Steroid Biochem Mol Biol 160:148-59|
|Arambula, Sheryl E; Belcher, Scott M; Planchart, Antonio et al. (2016) Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study. Endocrinology 157:3856-3872|
|Johnson, Sarah A; Javurek, Angela B; Painter, Michele S et al. (2016) Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study. Horm Behav 80:139-148|
|Rebuli, Meghan E; Camacho, Luísa; Adonay, Maria E et al. (2015) Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study. Toxicol Sci 148:341-54|
|León-Olea, Martha; Martyniuk, Christopher J; Orlando, Edward F et al. (2014) Current concepts in neuroendocrine disruption. Gen Comp Endocrinol 203:158-173|