Human exposure to Bisphenol A (BPA), found in polycarbonate plastics, epoxy resins, and carbonless thermal receipts, among other products, is nearly ubiquitous. Numerous studies by us and others in a range of species have shown that BPA exposure during critical windov /s of development alters sociosexual, mood, learning and memory-related behaviors raising concern that BPA exposure, particularly during gestation and early life, might be contributing to increased incidences of behavioral disorders in children and adults. Because most studies to date were not specifically designed to guide human risk assessment, leveraging the NTP/FDA chronic exposure study in Sprague Dawley rats to characterize how perinatal BPA exposure affects anxiety, memory-related, copulatory and mate preference behaviors during juvenile and adult life across three human-relevant doses will yield critical data that can inform public policy regarding the potential health effects of BPA. This proposed studies will test the hypothesis that BPA disrupts behavioral responses by altering sex specific developmental programming of the hippocampus and hypothalamus, potentially by altering the epigenetic landscape and subsequent gene expression. Worl

Public Health Relevance

Bisphenol A (BPA) is a high volume production chemical found in numerous household items from which it leaches including plastic containers, dental materials, and metallic can liners. We will examine as part ofthe NCTR/FDA study, whether early BPA exposure induces early molecular changes within the brain that lead to behavioral deficiencies, including increased anxiety and decreased memory in juveniles and adults.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01ES020929-04
Application #
8686850
Study Section
Special Emphasis Panel (ZES1-JAB-J (BP))
Program Officer
Heindel, Jerrold
Project Start
2011-09-19
Project End
2015-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
4
Fiscal Year
2014
Total Cost
$147,535
Indirect Cost
$19,891
Name
North Carolina State University Raleigh
Department
Biology
Type
Schools of Earth Sciences/Natur
DUNS #
042092122
City
Raleigh
State
NC
Country
United States
Zip Code
27695
León-Olea, Martha; Martyniuk, Christopher J; Orlando, Edward F et al. (2014) Current concepts in neuroendocrine disruption. Gen Comp Endocrinol 203:158-73