Influenza transmission and its resulting morbidity and mortality are of great concern to society. Strategic intervention may greatly reduce these factors, but the effectiveness of an intervention depends on public adherence, and, more generally, on individual decision making in response to actual and perceived health risks. This project aims to define optimal intervention strategies and policies that significantly improve intervention adherence for both epidemic and pandemic influenza outbreaks. To meet this objective, we will integrate knowledge and methods from epidemiology, mathematical modeling, economics, game theory, and experimental psychology. Contact patterns, which are often dynamic and highly variable, fundamentally influence the spread of disease. These patterns change as individuals make decisions to be vaccinated, accept treatment, take hygienic precautions, or avoid work, school, or public spaces. We will develop new epidemiological models that explicitly consider individual-level perceptions and decisions and their impacts on the contact networks underlying influenza transmission. These models will capture the evolutionary dynamics of influenza, including antigenic drift and the emergence of antiviral resistance. We will apply game-theoretical methods to these models to evaluate different influenza intervention strategies, including vaccination, antiviral-based interventions, and non-pharmaceutical interventions, and to identify strategic opportunities for improving adherence through informational and incentive programs that change individual perceptions and decisions. The contact patterns and psychological components of the models will be based on Bayesian analysis of census data, workflow and recreational mobility data, and real-time influenza surveillance data, as well as on survey studies that evaluate public knowledge and perceptions about the disease. The latter will also provide information on adherence behavior, contact patterns, and the impact of real-time influenza-related decisions on these patterns. Integrating realistic, perception-driven individual-level decision making into epidemiological models will facilitate the evaluation of interventions and the development of strategies to improve adherence both in epidemic and pandemic outbreaks of influenza. Public Health Relevance: By integrating realistic, perception-driven individual-level decision making into epidemiological models, this project will advance methods for predicting the success of interventions and for developing effective strategies for improving intervention adherence.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01GM087719-04
Application #
8269947
Study Section
Special Emphasis Panel (ZGM1-CBCB-5 (MI))
Program Officer
Sheeley, Douglas
Project Start
2009-06-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
4
Fiscal Year
2012
Total Cost
$529,525
Indirect Cost
$151,904
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Sempa, Joseph B; Dushoff, Jonathan; Daniels, Michael J et al. (2016) Reevaluating Cumulative HIV-1 Viral Load as a Prognostic Predictor: Predicting Opportunistic Infection Incidence and Mortality in a Ugandan Cohort. Am J Epidemiol 184:67-77
Parpia, Alyssa S; Ndeffo-Mbah, Martial L; Wenzel, Natasha S et al. (2016) Effects of Response to 2014-2015 Ebola Outbreak on Deaths from Malaria, HIV/AIDS, and Tuberculosis, West Africa. Emerg Infect Dis 22:433-41
Durham, David P; Ndeffo-Mbah, Martial L; Skrip, Laura A et al. (2016) National- and state-level impact and cost-effectiveness of nonavalent HPV vaccination in the United States. Proc Natl Acad Sci U S A 113:5107-12
Eggo, Rosalind M; Scott, James G; Galvani, Alison P et al. (2016) Respiratory virus transmission dynamics determine timing of asthma exacerbation peaks: Evidence from a population-level model. Proc Natl Acad Sci U S A 113:2194-9
Atkins, Katherine E; Pandey, Abhishek; Wenzel, Natasha S et al. (2016) Retrospective Analysis of the 2014-2015 Ebola Epidemic in Liberia. Am J Trop Med Hyg 94:833-9
Gilbert, Jennifer A; Medlock, Jan; Townsend, Jeffrey P et al. (2016) Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis. PLoS Negl Trop Dis 10:e0004465
Biggerstaff, Matthew; Alper, David; Dredze, Mark et al. (2016) Results from the centers for disease control and prevention's predict the 2013-2014 Influenza Season Challenge. BMC Infect Dis 16:357
Ndeffo-Mbah, Martial L; Durham, David P; Skrip, Laura A et al. (2016) Evaluating the effectiveness of localized control strategies to curtail chikungunya. Sci Rep 6:23997
Fallah, Mosoka P; Skrip, Laura A; Gertler, Shai et al. (2015) Quantifying Poverty as a Driver of Ebola Transmission. PLoS Negl Trop Dis 9:e0004260
Greenhalgh, Scott; Galvani, Alison P; Medlock, Jan (2015) Disease elimination and re-emergence in differential-equation models. J Theor Biol 387:174-80

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