Influenza transmission and its resulting morbidity and mortality are of great concern to society. Strategic intervention may greatly reduce these factors, but the effectiveness of an intervention depends on public adherence, and, more generally, on individual decision making in response to actual and perceived health risks. This project aims to define optimal intervention strategies and policies that significantly improve intervention adherence for both epidemic and pandemic influenza outbreaks. To meet this objective, we will integrate knowledge and methods from epidemiology, mathematical modeling, economics, game theory, and experimental psychology. Contact patterns, which are often dynamic and highly variable, fundamentally influence the spread of disease. These patterns change as individuals make decisions to be vaccinated, accept treatment, take hygienic precautions, or avoid work, school, or public spaces. We will develop new epidemiological models that explicitly consider individual-level perceptions and decisions and their impacts on the contact networks underlying influenza transmission. These models will capture the evolutionary dynamics of influenza, including antigenic drift and the emergence of antiviral resistance. We will apply game-theoretical methods to these models to evaluate different influenza intervention strategies, including vaccination, antiviral-based interventions, and non-pharmaceutical interventions, and to identify strategic opportunities for improving adherence through informational and incentive programs that change individual perceptions and decisions. The contact patterns and psychological components of the models will be based on Bayesian analysis of census data, workflow and recreational mobility data, and real-time influenza surveillance data, as well as on survey studies that evaluate public knowledge and perceptions about the disease. The latter will also provide information on adherence behavior, contact patterns, and the impact of real-time influenza-related decisions on these patterns. Integrating realistic, perception-driven individual-level decision making into epidemiological models will facilitate the evaluation of interventions and the development of strategies to improve adherence both in epidemic and pandemic outbreaks of influenza. Public Health Relevance: By integrating realistic, perception-driven individual-level decision making into epidemiological models, this project will advance methods for predicting the success of interventions and for developing effective strategies for improving intervention adherence.

Public Health Relevance

By integrating realistic, perception-driven individual-level decision making into epidemiological models, this project will advance methods for predicting the success of interventions and for developing effective strategies for improving intervention adherence.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZGM1-CBCB-5 (MI))
Program Officer
Sheeley, Douglas
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Yale University
Public Health & Prev Medicine
Schools of Medicine
New Haven
United States
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Pandey, Abhishek; Atkins, Katherine E; Medlock, Jan et al. (2014) Strategies for containing Ebola in West Africa. Science 346:991-5
Johnson, Matthew P; Gutfraind, Alexander; Ahmadizadeh, Kiyan (2014) Evader Interdiction: Algorithms, Complexity and Collateral Damage. Ann Oper Res 222:341-359
Lewnard, Joseph A; Ndeffo Mbah, Martial L; Alfaro-Murillo, Jorge A et al. (2014) Dynamics and control of Ebola virus transmission in Montserrado, Liberia: a mathematical modelling analysis. Lancet Infect Dis 14:1189-95
Ndeffo Mbah, Martial L; Durham, David P; Medlock, Jan et al. (2014) Country- and age-specific optimal allocation of dengue vaccines. J Theor Biol 342:15-22
Fitzpatrick, Meagan C; Hampson, Katie; Cleaveland, Sarah et al. (2014) Cost-effectiveness of canine vaccination to prevent human rabies in rural Tanzania. Ann Intern Med 160:91-100
von Terzi, Britta; Turnbull, Peter C B; Bellan, Steve E et al. (2014) Failure of Sterne- and Pasteur-like strains of Bacillus anthracis to replicate and survive in the urban bluebottle blow fly Calliphora vicina under laboratory conditions. PLoS One 9:e83860
Lipsitch, Marc; Galvani, Alison P (2014) Ethical alternatives to experiments with novel potential pandemic pathogens. PLoS Med 11:e1001646
Bellan, Steve E; Turnbull, Peter C B; Beyer, Wolfgang et al. (2013) Effects of experimental exclusion of scavengers from carcasses of anthrax-infected herbivores on Bacillus anthracis sporulation, survival, and distribution. Appl Environ Microbiol 79:3756-61
Ndeffo Mbah, Martial L; Poolman, Eric M; Atkins, Katherine E et al. (2013) Potential cost-effectiveness of schistosomiasis treatment for reducing HIV transmission in Africa--the case of Zimbabwean women. PLoS Negl Trop Dis 7:e2346
Ndeffo Mbah, Martial L; Medlock, Jan; Meyers, Lauren Ancel et al. (2013) Optimal targeting of seasonal influenza vaccination toward younger ages is robust to parameter uncertainty. Vaccine 31:3079-89

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