Public Health Relevance

Tight junctions are junctions between cells that are needed for epithelia (e.g. skin, kidney, intestine) to act as barriers. This proposal would determine the structure of proteins in the membrane ofthe tight junction and use this information to elucidate the mechanism by which they function. This work has widespread significance for understanding diseases due to epithelial barrier dysfunction

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01GM094627-03
Application #
8380062
Study Section
Special Emphasis Panel (ZGM1-CBB-0)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$319,764
Indirect Cost
$107,642
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
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Chen, Li; Zhou, Xia; Fan, Lucy X et al. (2015) Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest 125:2399-412
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Hou, Jianghui; Rajagopal, Madhumitha; Yu, Alan S L (2013) Claudins and the kidney. Annu Rev Physiol 75:479-501
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Yu, Alan S L (2011) Electrophysiological characterization of claudin ion permeability using stably transfected epithelial cell lines. Methods Mol Biol 762:27-41