Public Health Relevance

Tight junctions are junctions between cells that are needed for epithelia (e.g. skin, kidney, intestine) to act as barriers. This proposal would determine the structure of proteins in the membrane ofthe tight junction and use this information to elucidate the mechanism by which they function. This work has widespread significance for understanding diseases due to epithelial barrier dysfunction

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01GM094627-04
Application #
8516057
Study Section
Special Emphasis Panel (ZGM1-CBB-0)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$308,754
Indirect Cost
$74,741
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Laghaei, Rozita; Yu, Alan S L; Coalson, Rob D (2016) Water and ion permeability of a claudin model: A computational study. Proteins 84:305-15
Rosenthal, R; Günzel, D; Krug, S M et al. (2016) Claudin-2-mediated cation and water transport share a common pore. Acta Physiol (Oxf) :
Chen, Li; Zhou, Xia; Fan, Lucy X et al. (2015) Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest 125:2399-412
Yu, Alan S L (2015) Claudins and the kidney. J Am Soc Nephrol 26:11-9
Li, Jiahua; Zhuo, Min; Pei, Lei et al. (2014) Comprehensive cysteine-scanning mutagenesis reveals Claudin-2 pore-lining residues with different intrapore locations. J Biol Chem 289:6475-84
Gunzel, Dorothee; Yu, Alan S L (2013) Claudins and the modulation of tight junction permeability. Physiol Rev 93:525-69
Li, Jiahua; Angelow, Susanne; Linge, Anna et al. (2013) Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines. Am J Physiol Cell Physiol 305:C190-6
Li, Jiahua; Zhuo, Min; Pei, Lei et al. (2013) Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b. J Biol Chem 288:22790-7
Hou, Jianghui; Rajagopal, Madhumitha; Yu, Alan S L (2013) Claudins and the kidney. Annu Rev Physiol 75:479-501
Krug, Susanne M; Gunzel, Dorothee; Conrad, Marcel P et al. (2012) Charge-selective claudin channels. Ann N Y Acad Sci 1257:20-8

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