Public Health Relevance

This is a critical area of Human Health. Cell adhesion complexes are important in all aspects of normal cell and tissue function, and are commonly defective in genetic diseases and cancers. Results will provide new understanding of how defects disrupt normal function and contribute to disease, and potentially identify new therapeutic targets.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01GM094663-04S1
Application #
8814967
Study Section
Special Emphasis Panel (ZGM1-CBB-0)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2014
Total Cost
$74,945
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Dassama, Laura M K; Kenney, Grace E; Ro, Soo Y et al. (2016) Methanobactin transport machinery. Proc Natl Acad Sci U S A 113:13027-13032
Clarke, Donald Nathaniel; Miller, Phillip W; Lowe, Christopher J et al. (2016) Characterization of the Cadherin-Catenin Complex of the Sea Anemone Nematostella vectensis and Implications for the Evolution of Metazoan Cell-Cell Adhesion. Mol Biol Evol 33:2016-29
Choi, Hee-Jung; Weis, William I (2016) Purification and Structural Analysis of Desmoplakin. Methods Enzymol 569:197-213
Choi, Hee-Jung; Loveless, Timothy; Lynch, Allison M et al. (2015) A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo. Dev Cell 33:82-93
Bianchini, Julie M; Kitt, Khameeka N; Gloerich, Martijn et al. (2015) Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras. J Cell Biol 210:1065-74
Karginov, Andrei V; Tsygankov, Denis; Berginski, Matthew et al. (2014) Dissecting motility signaling through activation of specific Src-effector complexes. Nat Chem Biol 10:286-90
Pokutta, Sabine; Choi, Hee-Jung; Ahlsen, Goran et al. (2014) Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation. J Biol Chem 289:13589-601
Chu, Pei-Hsuan; Tsygankov, Denis; Berginski, Matthew E et al. (2014) Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc Natl Acad Sci U S A 111:12420-5
Buckley, Craig D; Tan, Jiongyi; Anderson, Karen L et al. (2014) Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force. Science 346:1254211
Slattery, Scott D; Hahn, Klaus M (2014) A High-Content Assay for Biosensor Validation and for Examining Stimuli that Affect Biosensor Activity. Curr Protoc Cell Biol 65:14.15.1-31

Showing the most recent 10 out of 23 publications