SPECIFIC AIMS of Southern California WIHS Consortium (SCWC) include: (1) To serve as a source for WIHS data and specimens;(2) To function in a manner which is critical to the success of WIHS-wide scientific studies;(3) To maintain the cohort, including active participation in approved sub-studies, as well as data and specimen collection;(4) To maintain relations with relevant community groups;(5) To provide epidemiologic expertise in study design and analysis to the local and national WIHS. BACKGROUND AND PRELIMINARY DATA: SCWC is comprised of 4 sites: the central site at USC School of Medicine/LAC-USC Medical Center;PROTOTYPES;Santa Barbara County Health Services;and Hawaii AIDS Research Consortia. Our cohort is the 3rd largest in the WIHS. Compliance with sub-studies and other requirements has been well above average throughout WIHS III. SCWC has contributed to the scientific mission of the study during WIHS III by (1) serving as first and/or last authors on 19 peer reviewed publications, with 4 additional manuscripts recently submitted;(2) providing leadership in the area of cardiovascular disease, with initial protocols for carotid intimal thickening studies, training of all WIHS sites, and on-going central reading of CITs performed by Drs. Howard Hodis and Wendy Mack at SCWC;(3) providing leadership in the area of Genomics, with development of a WIHS DNA Biorepository, housed at USC, under the direction of Dr. Leigh Pearce, with further expertise provided by Drs. David Van Den Berg, Daniel Stram, and David Conti. Dr. Pearce also serves as Chair of the national Genomics Working Group of WIHS, and has presented the first study from the WIHS in the area of genomics (CROI, 2/07). (4) providing leadership hematologic and malignant aspects of HIV in the cohort, with the expertise of Dr. AM Levine (PI);(5) providing leadership in the area of HCV and viral co-infections, under the direction of Drs. Andrea Kovacs, Marek Nowicki, and Maria Villacres. FUTURE PLANS: (1) We will continue as leaders in Genomics, implementing and maintaining the WIHS DNA Biorepository, while supporting internal and external investigators in WIHS-related genomics research;(2) We will provide expertise in immunology/ inflammation, to advance the scientific agenda of the WIHS;(3) We will provide expertise to the cardiovascular and HPV/cancer agendas, and in epidemiology (4) We will continue to maintain the SCWC cohort.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HD032632-19
Application #
8196754
Study Section
Special Emphasis Panel (ZAI1-LW-A (S1))
Program Officer
Mofenson, Lynne M
Project Start
1993-08-01
Project End
2014-11-30
Budget Start
2011-12-01
Budget End
2014-11-30
Support Year
19
Fiscal Year
2012
Total Cost
$2,795,907
Indirect Cost
$1,237,669
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Peralta, Ca; Scherzer, R; Grunfeld, C et al. (2014) Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS). HIV Med 15:291-300
Frasco, Melissa A; Karim, Roksana; Van Den Berg, David et al. (2014) Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women. AIDS 28:1815-23
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Landay, Alan; Golub, Elizabeth T; Desai, Seema et al. (2014) HIV RNA levels in plasma and cervical-vaginal lavage fluid in elite controllers and HAART recipients. AIDS 28:739-43
Mata, Mariana M; Iwema, Joyce R; Dell, Shanna et al. (2014) Comparison of antibodies that mediate HIV type 1 gp120 antibody-dependent cell-mediated cytotoxicity in asymptomatic HIV type 1-positive men and women. AIDS Res Hum Retroviruses 30:50-7
Aka, Peter V; Kuniholm, Mark H; Pfeiffer, Ruth M et al. (2014) Association of the IFNL4-?G Allele With Impaired Spontaneous Clearance of Hepatitis C Virus. J Infect Dis 209:350-4
Pyra, Maria; Weber, Kathleen; Wilson, Tracey E et al. (2014) Sexual minority status and violence among HIV infected and at-risk women. J Gen Intern Med 29:1131-8
Torre 3rd, Peter; Hoffman, Howard J; Springer, Gayle et al. (2014) Cochlear function among HIV-seropositive and HIV-seronegative men and women. Ear Hear 35:56-62
Hessol, Nancy A; Weber, Kathleen M; D'Souza, Gypsyamber et al. (2014) Smoking cessation and recidivism in the Women's Interagency Human Immunodeficiency Virus Study. Am J Prev Med 47:53-69

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