The University of South Florida, Tampa Bay Adolescent Trials Unity (TB AMTU) provides primary and specialty care, prevention services and access to clinical trials to HIV infected and at-risk youth in the Tampa Bay area. To sustain and expand these services, the TB AMTU proposes the following specific aims for this proposal: 1) Engage, enroll and retain HIV-infected youth in care and research through a mature clinical and research infrastructure and innovative programs which adapt to the changes in the HIV epidemic, 2) Mobilize and connect the Tampa Bay community in an innovative collaborative effort to address the challenges of the HIV epidemic in youth and young adults, 3) Contribute to the national adolescent HIV agenda by drawing on the strengths of the university environment and an interdisciplinary research network that participates on the design and execution of ATN protocols and engages and supports new investigators. The objectives established support these aims. It is the intent of the TB AMTU to continue to provide a seamless continuum of comprehensive care, address the mental health needs of those served, and support the emerging autonomy of HIV infected youth. The TB AMTU will collaborate with the ATN leadership group to develop clinical trials that address primary, secondary and tertiary HIV prevention and expand services that allow for the implementation of this broad research agenda. To support these efforts, the TB AMTU will continue to build community capacity and enhance successful relationships with its Connect to Protect Partners in executing structural change objectives. New initiatives will include stronger linkage to care processes, enhanced referral networks for Young Men who have Sex with Men (YMSM) and the implementation of a specialty clinic for GLBTQ and other alternative youth.

Public Health Relevance

The TB AMTU responds to the national public health agenda that emphasize the need to address the disproportionate impact of HIV on minority populations by supporting efforts to engage, recruit and retain youth of racial/ethnic and other minority populations. The unit proactively works to reduce the incidence of HIV in these populations and improve the quality of life for those already infected.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project--Cooperative Agreements (U01)
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Study Section
Special Emphasis Panel (ZHD1)
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Russo, Denise
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University of South Florida
Schools of Medicine
United States
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Harper, Gary W; Tyler, April Timmons; Bruce, Douglas et al. (2016) Drugs, Sex, and Condoms: Identification and Interpretation of Race-Specific Cultural Messages Influencing Black Gay and Bisexual Young Men Living with HIV. Am J Community Psychol 58:463-476
Rudy, Bret J; Kapogiannis, Bill G; Worrell, Carol et al. (2015) Immune Reconstitution but Persistent Activation After 48 Weeks of Antiretroviral Therapy in Youth With Pre-Therapy CD4 >350 in ATN 061. J Acquir Immune Defic Syndr 69:52-60
Havens, Peter L; Hazra, Rohan; Stephensen, Charles B et al. (2014) Vitamin D3 supplementation increases fibroblast growth factor-23 in HIV-infected youths treated with tenofovir disoproxil fumarate. Antivir Ther 19:613-8
Harper, Gary W; Bruce, Douglas; Hosek, Sybil G et al. (2014) Resilience processes demonstrated by young gay and bisexual men living with HIV: implications for intervention. AIDS Patient Care STDS 28:666-76
Porter, Travis R; Li, Xuelin; Stephensen, Charles B et al. (2013) Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: fine-mapping for the GC/DBP gene that encodes the vitamin D-binding protein. Front Genet 4:234
Harper, Gary W; Fernandez, Isabel M; Bruce, Douglas et al. (2013) The role of multiple identities in adherence to medical appointments among gay/bisexual male adolescents living with HIV. AIDS Behav 17:213-23
Havens, Peter L; Kiser, Jennifer J; Stephensen, Charles B et al. (2013) Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency? Antimicrob Agents Chemother 57:5619-28
Lee, Sonia; Kapogiannis, Bill G; Flynn, Patricia M et al. (2013) Comprehension of a simplified assent form in a vaccine trial for adolescents. J Med Ethics 39:410-2
Harper, Gary W; Willard, Nancy; Ellen, Jonathan M et al. (2012) Connect to Protect®: utilizing community mobilization and structural change to prevent HIV infection among youth. J Prev Interv Community 40:81-6
Havens, Peter L; Mulligan, Kathleen; Hazra, Rohan et al. (2012) Serum 25-hydroxyvitamin D response to vitamin D3 supplementation 50,000 IU monthly in youth with HIV-1 infection. J Clin Endocrinol Metab 97:4004-13

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