RTI International (RTI), as the proposed data coordinating center (DCC) for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Global Network (GN), will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations across diverse research settings in multiple low-income countries. To achieve this aim, RTI will (1) provide scientific and statistical leadership to facilitate feasible, scientificaly sound, and clinically relevant protocols;(2) develop and support innovative, robust, secure, and locally sustainable data management systems (DMSs) that enhance the implementation of the study protocols and increase local research capacity;(3) develop effective data monitoring and safety reports that facilitate study management and oversight;(4) facilitate collaborative, high-quality GN study publications through rigorous analyses and logistical and editorial support;(5) coordinate the acquisition, storage, and tracking of study drugs, equipment, and supplies;and (6) promote efficient study development and implementation through logistical communication support of the GN protocol teams and the External Advisory Board and the Data Safety and Monitoring Board. RTI brings specific strengths that will support the GN's mission to enhance the global research capacity to improve health of women and children in low-income countries: (1) proven scientific collaboration in the leadership of the GN over the past 11 years as demonstrated by the more than 110 collaborative GN manuscripts and the collaboration of E. McClure in extending GN capacity through collaboration with external funding sources;(2) a set of state-of-the art, flexible, established distributed data entry and management tools that will (a ensure high-quality data with rapid error resolution, (b) provide creative solutions to difficult problems like drug distribution in rural areas, and (c) provide site staff with study management and reporting tools that enhance the scientific quality;and (3) statistical expertise in study design that has provided the GN with innovative cluster- and individually randomized designs and quality improvement approaches that address the unique scientific, implementation, cultural, and ethical issues encountered by the GN. Public Health Relevance: The Global Network for Women's and Children's Health Research (GN) is a multi-country research network developed to conduct research to identify solutions to reduce important causes of maternal and childhood mortality in developing countries. As the data coordinating center (DCC), RTI will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations by ensuring sound study design, high-quality data collection and analyses, and efficient communication across these diverse research settings.

Public Health Relevance

The Global Network for Women's and Children's Health Research (GN) is a multi-country research network developed to conduct research to identify solutions to reduce important causes of maternal and childhood mortality in developing countries. As the data coordinating center (DCC), RTI will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations by ensuring sound study design, high-quality data collection and analyses, and efficient communication across these diverse research settings.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01HD040636-12
Application #
8317375
Study Section
Special Emphasis Panel (ZHD1-DSR-M (50))
Program Officer
Koso-Thomas, Marion
Project Start
2001-08-17
Project End
2017-04-30
Budget Start
2012-06-26
Budget End
2013-04-30
Support Year
12
Fiscal Year
2012
Total Cost
$2,062,995
Indirect Cost
$760,184
Name
Research Triangle Institute
Department
Type
DUNS #
004868105
City
Research Triangle
State
NC
Country
United States
Zip Code
27709
Goldenberg, Robert L; Thorsten, Vanessa R; Althabe, Fernando et al. (2016) The global network antenatal corticosteroids trial: impact on stillbirth. Reprod Health 13:68
Bucher, Sherri; Konana, Olive; Liechty, Edward et al. (2016) Self-reported practices among traditional birth attendants surveyed in western Kenya: a descriptive study. BMC Pregnancy Childbirth 16:219
Garces, Ana; McClure, Elizabeth M; Figueroa, Lester et al. (2016) A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands. Reprod Health 13:63
Berrueta, Mabel; Hemingway-Foday, Jennifer; Thorsten, Vanessa R et al. (2016) Use of antenatal corticosteroids at health facilities and communities in low-and-middle income countries. Reprod Health 13:66
Althabe, Fernando; Thorsten, Vanessa; Klein, Karen et al. (2016) The Antenatal Corticosteroids Trial (ACT)'s explanations for neonatal mortality - a secondary analysis. Reprod Health 13:62
Klein, Karen; McClure, Elizabeth M; Colaci, Daniela et al. (2016) The Antenatal Corticosteroids Trial (ACT): a secondary analysis to explore site differences in a multi-country trial. Reprod Health 13:64
McClure, Elizabeth M; Goldenberg, Robert L; Jobe, Alan H et al. (2016) Reducing neonatal mortality associated with preterm birth: gaps in knowledge of the impact of antenatal corticosteroids on preterm birth outcomes in low-middle income countries. Reprod Health 13:61
Bang, Akash; Patel, Archana; Bellad, Roopa et al. (2016) Helping Babies Breathe (HBB) training: What happens to knowledge and skills over time? BMC Pregnancy Childbirth 16:364
Hibberd, Patricia L; Hansen, Nellie I; Wang, Marie E et al. (2016) Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study. Reprod Health 13:65
Pasha, Omrana; Goudar, Shivaprasad S; Patel, Archana et al. (2015) Postpartum contraceptive use and unmet need for family planning in five low-income countries. Reprod Health 12 Suppl 2:S11

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