RTI International (RTI), as the proposed data coordinating center (DCC) for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Global Network (GN), will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations across diverse research settings in multiple low-income countries. To achieve this aim, RTI will (1) provide scientific and statistical leadership to facilitate feasible, scientificaly sound, and clinically relevant protocols;(2) develop and support innovative, robust, secure, and locally sustainable data management systems (DMSs) that enhance the implementation of the study protocols and increase local research capacity;(3) develop effective data monitoring and safety reports that facilitate study management and oversight;(4) facilitate collaborative, high-quality GN study publications through rigorous analyses and logistical and editorial support;(5) coordinate the acquisition, storage, and tracking of study drugs, equipment, and supplies;and (6) promote efficient study development and implementation through logistical communication support of the GN protocol teams and the External Advisory Board and the Data Safety and Monitoring Board. RTI brings specific strengths that will support the GN's mission to enhance the global research capacity to improve health of women and children in low-income countries: (1) proven scientific collaboration in the leadership of the GN over the past 11 years as demonstrated by the more than 110 collaborative GN manuscripts and the collaboration of E. McClure in extending GN capacity through collaboration with external funding sources;(2) a set of state-of-the art, flexible, established distributed data entry and management tools that will (a ensure high-quality data with rapid error resolution, (b) provide creative solutions to difficult problems like drug distribution in rural areas, and (c) provide site staff with study management and reporting tools that enhance the scientific quality;and (3) statistical expertise in study design that has provided the GN with innovative cluster- and individually randomized designs and quality improvement approaches that address the unique scientific, implementation, cultural, and ethical issues encountered by the GN. Public Health Relevance: The Global Network for Women's and Children's Health Research (GN) is a multi-country research network developed to conduct research to identify solutions to reduce important causes of maternal and childhood mortality in developing countries. As the data coordinating center (DCC), RTI will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations by ensuring sound study design, high-quality data collection and analyses, and efficient communication across these diverse research settings.

Public Health Relevance

The Global Network for Women's and Children's Health Research (GN) is a multi-country research network developed to conduct research to identify solutions to reduce important causes of maternal and childhood mortality in developing countries. As the data coordinating center (DCC), RTI will provide the scientific and operational resources to maximize the scientific productivity and public health impact of the GN research collaborations by ensuring sound study design, high-quality data collection and analyses, and efficient communication across these diverse research settings.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HD040636-13
Application #
8497697
Study Section
Special Emphasis Panel (ZHD1-DSR-M (50))
Program Officer
Koso-Thomas, Marion
Project Start
2001-08-17
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$1,870,204
Indirect Cost
$792,819
Name
Research Triangle Institute
Department
Type
DUNS #
004868105
City
Research Triangle
State
NC
Country
United States
Zip Code
27709
Bang, Akash; Bellad, Roopa; Gisore, Peter et al. (2014) Implementation and evaluation of the Helping Babies Breathe curriculum in three resource limited settings: does Helping Babies Breathe save lives? A study protocol. BMC Pregnancy Childbirth 14:116
Wallander, Jan L; Bann, Carla; Chomba, Elwyn et al. (2014) Developmental trajectories of children with birth asphyxia through 36 months of age in low/low-middle income countries. Early Hum Dev 90:343-8
Wallander, Jan L; Bann, Carla M; Biasini, Fred J et al. (2014) Development of children at risk for adverse outcomes participating in early intervention in developing countries: a randomized controlled trial. J Child Psychol Psychiatry 55:1251-9
Saleem, Sarah; McClure, Elizabeth M; Goudar, Shivaprasad S et al. (2014) A prospective study of maternal, fetal and neonatal deaths in low- and middle-income countries. Bull World Health Organ 92:605-12
Wallander, Jan L; Biasini, Fred J; Thorsten, Vanessa et al. (2014) Dose of early intervention treatment during children's first 36 months of life is associated with developmental outcomes: an observational cohort study in three low/low-middle income countries. BMC Pediatr 14:281
McClure, Elizabeth M; Nathan, Robert O; Saleem, Sarah et al. (2014) First look: a cluster-randomized trial of ultrasound to improve pregnancy outcomes in low income country settings. BMC Pregnancy Childbirth 14:73
Marete, Irene; Tenge, Constance; Pasha, Omrana et al. (2014) Perinatal outcomes of multiple-gestation pregnancies in Kenya, Zambia, Pakistan, India, Guatemala, and Argentina: a global network study. Am J Perinatol 31:125-32
Pasha, Omrana; McClure, Elizabeth M; Wright, Linda L et al. (2013) A combined community- and facility-based approach to improve pregnancy outcomes in low-resource settings: a Global Network cluster randomized trial. BMC Med 11:215
Goldenberg, Robert L; McClure, Elizabeth M; Kodkany, Bhala et al. (2013) A multi-country study of the "intrapartum stillbirth and early neonatal death indicator" in hospitals in low-resource settings. Int J Gynaecol Obstet 122:230-3
Gisore, P; Rono, B; Marete, I et al. (2013) Commonly cited incentives in the community implementation of the emergency maternal and newborn care study in western Kenya. Afr Health Sci 13:461-8

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