Prenatal alcohol exposure has long been linked to deficits in neurodevelopmental, growth, and systemic functions in infants under the rubric of fetal alcohol spectrum disorders (FASD), with fetal alcohol syndrome at the most severe end of the spectrum. Yet, increasing epidemiologic, physiologic, and pathologic data suggest potential relationships between prenatal alcohol exposure and mortality, including the sudden infant death syndrome (SIDS) and stillbirth. These mortality data in conjunction with the morbidity data underscore the enormous personal and societal burden of maternal drinking during pregnancy, and the urgent need for more effective intervention strategies. The mission of the PASS Network is to perform community-linked studies to determine the role of prenatal alcohol exposure in the risk for SIDS and adverse pregnancy outcomes, especially stillbirth and FASD. This application proposes the completion of enrollment and follow- up of study participants and the performance of data analysis in Phase II of the PASS Network by the Northern Plains Comprehensive Clinical Site (NPCCS). To carry out the mission of the PASS Network, a highly skilled interdisciplinary team has been assembled at the NPCCS that has been working successfully together throughout Phase II. A community-based infrastructure serves as the foundation for the NPCCS that incorporates hospitals, prenatal clinics, pediatric clinics, medical examiner systems, pathology departments, social service agencies, tribal colleges and community review boards. In addition, the NPCCS is responsible for the design and analysis of the FASD case determinations through analysis of facial dysmorphology. The NPCCS conducts all of these activities within a management structure designed to optimize active recruitment and collection of high quality data with care and compassion for the participants and communities it serves.

Public Health Relevance

The potential impact of the Northern Plains CCS is to develop strategies to improve the care of mothers and their children in populations in which prenatal alcohol exposure is a significant public health problem, as delineated in the common section above.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project--Cooperative Agreements (U01)
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Application #
Study Section
Special Emphasis Panel (ZAA1-GG (02))
Program Officer
Raju, Tonse N
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Sanford Research/Usd
Sioux Falls
United States
Zip Code
Hofmeyr, F; Groenewald, C A; Nel, D G et al. (2014) Fetal heart rate patterns at 20 to 24 weeks gestation as recorded by fetal electrocardiography. J Matern Fetal Neonatal Med 27:714-8
Dukes, Kimberly A; Burd, Larry; Elliott, Amy J et al. (2014) The safe passage study: design, methods, recruitment, and follow-up approach. Paediatr Perinat Epidemiol 28:455-65
Paintner, Ashley; Williams, Andrew D; Burd, Larry (2012) Fetal alcohol spectrum disorders--implications for child neurology, part 2: diagnosis and management. J Child Neurol 27:355-62
Paintner, Ashley; Williams, Andrew D; Burd, Larry (2012) Fetal alcohol spectrum disorders-- implications for child neurology, part 1: prenatal exposure and dosimetry. J Child Neurol 27:258-63
Odendaal, Hein J; Elliott, Amy; Kinney, Hannah C et al. (2011) Consent for autopsy research for unexpected death in early life. Obstet Gynecol 117:167-71
Dempers, Johan; Wadee, Shabbir Ahmed; Boyd, Theonia et al. (2011) Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy: a case report. Pediatr Dev Pathol 14:71-4
Dempers, Johan; Sens, Mary Ann; Wadee, Shabbir Ahmed et al. (2011) Progressive primary pulmonary tuberculosis presenting as the sudden unexpected death in infancy: a case report. Forensic Sci Int 206:e27-30
Hofer, Ryan; Burd, Larry (2009) Review of published studies of kidney, liver, and gastrointestinal birth defects in fetal alcohol spectrum disorders. Birth Defects Res A Clin Mol Teratol 85:179-83
Burd, Larry; Christensen, Trent (2009) Treatment of fetal alcohol spectrum disorders: are we ready yet? J Clin Psychopharmacol 29:1-4
Burd, Larry; Klug, Marilyn G; Bueling, Robyn et al. (2008) Mortality rates in subjects with fetal alcohol spectrum disorders and their siblings. Birth Defects Res A Clin Mol Teratol 82:217-23

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