The Collaborative Pediatric Critical Care Research Network was established in 2005 to support multicenter randomized controlled trials and observational studies in critically ill children. In the first 46 months (May 2005 March 2009), CPCCRN has created a network registry, developed a novel functional status outcome scale, conducted several studies of pathologic bereavement, implemented a RCT to prevent nosocomial sepsis (requiring an IND from the FDA), and validated a novel method for measuring free serum Cortisol. CPCCRN has also collaborated with non-CPCCRN institutions to measure the burden of critical pertussis in the United States, and actively participated in developing an NHLBl-funded pediatric RCT of hypothermia after cardiac arrest. Going forward, the network has fully developed protocols in its pipeline to study opioid tolerance (MOTIF) and to identify usable outcomes for sepsis trials (COMPASS). CPCCRN investigators are developing computerized decision support tools for studies of pediatric mechanical ventilation. In the initial 46 months, CPCCRN activities have contributed to 11 peer-reviewed publications.The University of Utah is the Data Coordinating Center (DCC) for CPCCRN, and proposes to continue in this role during the next five years. The DCC faculty bring recognized clinical, biostatistical, and informatics expertise to the CPCCRN. This proposal has three specific aims.
Specific Aim 1. Provide clinical and biostatistical leadership and expertise, assistance in study and protocol design, study implementation and coordination, interim and final study analysis, tracking and delivery methods for study drugs and biological specimens, data collection and management, site monitoring, and active support for dissemination of study results.
Specific Aim 2. Provide logistical support for CPCCRN (including financial management of protocol funds), using advanced communication and informatics tools for development and tracking of critical documents, protocols. Manuals of Operation, publications, reports, and provision of accounting information to NICHD.
Specific Aim 3. Develop detailed computerized protocols for management of vasoactive drips, to support future potential CPCCRN studies of pediatric septic shock (DCC Concept Proposal).

Public Health Relevance

(See Instructions): The CPCCRN carries out clinical trials and studies to improve the science of pediatric intensive care and to reduce the mortality and improve the long term outcome for infants and children who suffer from critical illness or injury.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01HD049934-06
Application #
7797818
Study Section
Special Emphasis Panel (ZHD1-DSR-A (25))
Program Officer
Nicholson, Carol E
Project Start
2005-05-01
Project End
2014-11-30
Budget Start
2009-12-24
Budget End
2010-11-30
Support Year
6
Fiscal Year
2010
Total Cost
$3,126,696
Indirect Cost
Name
University of Utah
Department
Pediatrics
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Zane, Nicole R; Reedy, Michael D; Gastonguay, Marc R et al. (2017) A Population Pharmacokinetic Analysis to Study the Effect of Therapeutic Hypothermia on Vancomycin Disposition in Children Resuscitated From Cardiac Arrest. Pediatr Crit Care Med 18:e290-e297
Moler, Frank W; Silverstein, Faye S; Holubkov, Richard et al. (2017) Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med 376:318-329
Cashen, Katherine; Reeder, Ron; Dalton, Heidi J et al. (2017) Functional Status of Neonatal and Pediatric Patients After Extracorporeal Membrane Oxygenation. Pediatr Crit Care Med 18:561-570
Slomine, Beth S; Nadkarni, Vinay M; Christensen, James R et al. (2017) Pediatric cardiac arrest due to drowning and other respiratory etiologies: Neurobehavioral outcomes in initially comatose children. Resuscitation 115:178-184
Newth, Christopher J L; Sward, Katherine A; Khemani, Robinder G et al. (2017) Variability in Usual Care Mechanical Ventilation for Pediatric Acute Respiratory Distress Syndrome: Time for a Decision Support Protocol? Pediatr Crit Care Med 18:e521-e529
Carcillo, Joseph A; Sward, Katherine; Halstead, E Scott et al. (2017) A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis. Pediatr Crit Care Med 18:143-150
Carcillo, Joseph A; Halstead, E Scott; Hall, Mark W et al. (2017) Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. Pediatr Crit Care Med 18:513-523
Berger, John T; Holubkov, Richard; Reeder, Ron et al. (2017) Morbidity and mortality prediction in pediatric heart surgery: Physiological profiles and surgical complexity. J Thorac Cardiovasc Surg 154:620-628.e6
Moler, Frank W; Hutchison, Jamie S; Nadkarni, Vinay M et al. (2016) Targeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications. Pediatr Crit Care Med 17:712-20
Keele, Linda; Meert, Kathleen L; Berg, Robert A et al. (2016) Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed? Pediatr Crit Care Med 17:110-20

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