The Collaborative Pediatric Critical Care Research Network was established in 2005 to support multicenter randomized controlled trials and observational studies in critically ill children. In the first 46 months (May 2005 March 2009), CPCCRN has created a network registry, developed a novel functional status outcome scale, conducted several studies of pathologic bereavement, implemented a RCT to prevent nosocomial sepsis (requiring an IND from the FDA), and validated a novel method for measuring free serum Cortisol. CPCCRN has also collaborated with non-CPCCRN institutions to measure the burden of critical pertussis in the United States, and actively participated in developing an NHLBl-funded pediatric RCT of hypothermia after cardiac arrest. Going forward, the network has fully developed protocols in its pipeline to study opioid tolerance (MOTIF) and to identify usable outcomes for sepsis trials (COMPASS). CPCCRN investigators are developing computerized decision support tools for studies of pediatric mechanical ventilation. In the initial 46 months, CPCCRN activities have contributed to 11 peer-reviewed publications.The University of Utah is the Data Coordinating Center (DCC) for CPCCRN, and proposes to continue in this role during the next five years. The DCC faculty bring recognized clinical, biostatistical, and informatics expertise to the CPCCRN. This proposal has three specific aims.
Specific Aim 1. Provide clinical and biostatistical leadership and expertise, assistance in study and protocol design, study implementation and coordination, interim and final study analysis, tracking and delivery methods for study drugs and biological specimens, data collection and management, site monitoring, and active support for dissemination of study results.
Specific Aim 2. Provide logistical support for CPCCRN (including financial management of protocol funds), using advanced communication and informatics tools for development and tracking of critical documents, protocols. Manuals of Operation, publications, reports, and provision of accounting information to NICHD.
Specific Aim 3. Develop detailed computerized protocols for management of vasoactive drips, to support future potential CPCCRN studies of pediatric septic shock (DCC Concept Proposal).

Public Health Relevance

The CPCCRN carries out clinical trials and studies to improve the science of pediatric intensive care and to reduce the mortality and improve the long term outcome for infants and children who suffer from critical illness or injury.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZHD1-DSR-A (25))
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Maholmes, Valerie
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University of Utah
Schools of Medicine
Salt Lake City
United States
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Holubkov, Richard; Clark, Amy E; Moler, Frank W et al. (2015) Efficacy outcome selection in the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med 16:10-Jan
Pollack, Murray M; Holubkov, Richard; Funai, Tomohiko et al. (2014) Relationship between the functional status scale and the pediatric overall performance category and pediatric cerebral performance category scales. JAMA Pediatr 168:671-6
Jardine, David; Emond, Mary; Meert, Kathleen L et al. (2014) A single nucleotide polymorphism in the corticotropin receptor gene is associated with a blunted cortisol response during pediatric critical illness. Pediatr Crit Care Med 15:698-705
Topjian, Alexis A; French, Benjamin; Sutton, Robert M et al. (2014) Early postresuscitation hypotension is associated with increased mortality following pediatric cardiac arrest. Crit Care Med 42:1518-23
Meert, Kathleen L; Eggly, Susan; Berg, Robert A et al. (2014) Feasibility and perceived benefits of a framework for physician-parent follow-up meetings after a child's death in the PICU. Crit Care Med 42:148-57
Topjian, Alexis; French, Benjamin; Sutton, Robert M et al. (2014) The authors reply. Crit Care Med 42:e808-9
Topjian, Alexis A; Clark, Amy E; Casper, T Charles et al. (2013) Early lactate elevations following resuscitation from pediatric cardiac arrest are associated with increased mortality*. Pediatr Crit Care Med 14:e380-7
Moler, Frank W; Silverstein, Faye S; Meert, Kathleen L et al. (2013) Rationale, timeline, study design, and protocol overview of the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med 14:e304-15
Heidemann, Sabrina M; Holubkov, Richard; Meert, Kathleen L et al. (2013) Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children. Pediatr Crit Care Med 14:e202-6
Berger, John T; Carcillo, Joseph A; Shanley, Thomas P et al. (2013) Critical pertussis illness in children: a multicenter prospective cohort study. Pediatr Crit Care Med 14:356-65

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