As requested by RFA-HD-04-002 entitled """"""""Genomic and Proteomic Network for Premature Birth Research,"""""""" we propose to establish a Data Management, Statistics, and Informatics Core at Yale University as a part of the Network. We will be responsible for the central database, data analysis, and management;information technology;and coordination of the administrative activities of the Network. We have assembled a team of investigators with extensive experience in all of these areas, and we have collaborated closely and successfully in related activities. Specifically, as a part of the Network, we will (1) establish and maintain a central database, data analysis, information technology;(2) collaborate with investigators in the three clinical cores to define the study hypotheses and play a leadership role in the study design;(3) interact with investigators in the analytic core for analyzing genomic and proteomic data;(4) establish and maintain a public, web-based, genomic and proteomic database for data mining and data deposition by the research community as well as within our network;(5) participate in the steering committee of the network, coordinate and administrate activities central to the network and communicate regularly with the NICHD program staff and the network investigators;(6) participate in manuscript preparation and publication with the network investigators, and disseminate scientific results timely through the network website;(7) initiate our own research activities consistent with the goal of the RFA, namely to hasten a deeper understanding of the patho-physiology of premature birth, discover novel target molecules and diagnostic biomarkers, and ultimately aid in formulating more effective interventions to prevent premature birth.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (ZHD1-DSR-T (02))
Program Officer
Spong, Catherine
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Yale University
Public Health & Prev Medicine
Schools of Medicine
New Haven
United States
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