Despite the vast diversity of its populations, genetic studies in Africa have been limited. African populations, Malians in particular, have a high rate o intra-ethnic and consanguineous marriage, resulting in increased prevalence of autosomal recessive diseases. Family-based genetic studies can be limited in developed countries due to small sib ships. The average fertility rate in Mali is over 6 births per woman, offering a unique opportunity to find new disease genes or mutations that can then be studied in other populations. Hereditary neurological diseases are very debilitating diseases, and developing countries, particularly in Africa, pay a high price in terms of disability-adjusted life years. Although most are currently untreatable, increasing awareness about hereditary neurological disorders can reduce this burden. This study will help to identify and characterize novel hereditary neurological disease genes in Mali. These genes are likely to be important in the normal function of the nervous system and to have important pathophysiological implications for African and other populations. This study will also train physicians and students in the characterization of neurodegenerative diseases as well as in genetic technology and molecular biology, and build a suitable research environment that will retain them.

Public Health Relevance

The goal of this project is to clinically and genetically characterize Malian patients with hereditary neurological disorders, and to study the effects of putative sequence variants in cell models. It will allow training for physicians and students in genetics and molecular biology, and increase awareness about these conditions in the general population.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01HG007044-01A1
Application #
8576339
Study Section
Special Emphasis Panel (ZHG1-HGR-P (M2))
Program Officer
Guyer, Mark S
Project Start
2013-09-27
Project End
2017-07-31
Budget Start
2013-09-27
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$341,580
Indirect Cost
$12,118
Name
University of Bamako
Department
Type
DUNS #
565539819
City
Bamako
State
Country
Mali
Zip Code
BP E2-528