Out-of-hospital cardiopulmonary arrest (OOH-CA) and life-threatening traumatic injury (LTI), including traumatic brain injury, have been jointly investigated since they share several common features. The Clinical Trial Center (CTC) for a Resuscitation Research Consortium has played a central role in conducting clinical trials in the areas of OOH-CA and LTI. With the goal of improving resuscitation outcomes, the CTC has the following aims: 1) To provide administrative and statistical leadership for clinical trials in OOHCA an d LTI including all phases of currently conducted trials. 2) To continue our observational study of care processes and outcomes for emergency medical services (EMS) care through the Epistry registry. 3) To rapidly design, and implement a series of high-quality Phase II and Phase III randomized trials that have high internal and external validity. 4) To maintain and improve an efficient and secure information technology system for collection, processing, storage, and quality control of the data. 5) To take the lead and/or collaborate regarding timely dissemination of knowledge within the consortium, with sponsors, oversight bodies, and the scientific community, thereby improving resuscitation outcomes. 6) To provide methodological leadership for clinical trials in OOH-CA and LTI. The CTC will draw upon its extensive experience with community emergency service providers, emergency physicians and cardiologists to actively collaborate with highly-qualified clinicians working in OOH-CA or LTI research at each regional clinical center (RCC). The Center has and will continue to make substantial contributions to all aspects of clinical trial design, implementation and conduct based on its statistical, administrative and medical expertise. The Data Coordinating Center will enhance an existing interactive information technology system to facilitate communication and development. Robust, secure and confidential methods of data management and quality control will be used to provide a central repository for timely acquisition of data, so that prompt careful analyses can be conducted. Multiple strategies will be used to ensure timely and effective dissemination of study results to policy makers, practitioners, and the public in order to improve EMS-related health care delivery in the United States and Canada.

Public Health Relevance

The Resuscitation Outcomes Consortium (ROC) will provide administrative leadership for clinical trials in the area of out-of-hospital cardiopulmonary arrest and life-threatening traumatic injury. The Consortium is a group of 9 regional clinical centers within the United States and Canada.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-I (01))
Program Officer
Sopko, George
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Biostatistics & Other Math Sci
Schools of Public Health
United States
Zip Code
Fink, Ericka L; Prince, David K; Kaltman, Jonathan R et al. (2016) Unchanged pediatric out-of-hospital cardiac arrest incidence and survival rates with regional variation in North America. Resuscitation 107:121-8
Kurz, Michael Christopher; Prince, David K; Christenson, James et al. (2016) Association of advanced airway device with chest compression fraction during out-of-hospital cardiopulmonary arrest. Resuscitation 98:35-40
Evans, Christopher C D; Petersen, Ashley; Meier, Eric N et al. (2016) Prehospital traumatic cardiac arrest: Management and outcomes from the resuscitation outcomes consortium epistry-trauma and PROPHET registries. J Trauma Acute Care Surg 81:285-93
Stephens, Shannon W; Williams, Carolyn; Gray, Randal et al. (2016) Using social media for community consultation and public disclosure in exception from informed consent trials. J Trauma Acute Care Surg 80:1005-9
Rizoli, Sandro; Petersen, Ashley; Bulger, Eileen et al. (2016) Early prediction of outcome after severe traumatic brain injury: a simple and practical model. BMC Emerg Med 16:32
Morrison, Laurie J; Schmicker, Robert H; Weisfeldt, Myron L et al. (2016) Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium. Resuscitation 100:76-81
Undurraga Perl, Vicente J; Leroux, Brian; Cook, Mackenzie R et al. (2016) Damage-control resuscitation and emergency laparotomy: Findings from the PROPPR study. J Trauma Acute Care Surg 80:568-74; discussion 574-5
Mumma, Bryn E; Umarov, Temur (2016) Sex differences in the prehospital management of out-of-hospital cardiac arrest. Resuscitation 105:161-4
Salcido, David D; Torres, Cesar; Koller, Allison C et al. (2016) Regional incidence and outcome of out-of-hospital cardiac arrest associated with overdose. Resuscitation 99:13-9
Deguchi, Hiroshi; Sinha, Ranjeet K; Marchese, Patrizia et al. (2016) Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. Blood :

Showing the most recent 10 out of 129 publications