The Resuscitation Outcomes Consortium (ROC), consisting of 9 Regional Clinical Centers and a Data and Coordinating Center, is conducting multiple collaborative trials to achieve its long-term objective of rapid translation of promising scientific and clinical advances to improve resuscitation outcomes in the out-of hospital setting. Having established unprecedented infrastructure to successfully accomplish this goal (using exception from informed consent under emergency circumstances) in 245 EMS agencies and nearly 35,000 EMS providers covering a population of over 22 million people throughout North America, ROC has already demonstrated its ability to rapidly advance the fields of emergency cardiac and trauma care. This proposal presents the rationale for a 6-year renewal of funding for ROC to continue to improve outcomes for these important national healthcare issues. Three of the specific aims of the Consortium are to further advance these fields by: 1) continuing to expand and investigate the cardiac arrest and traumatic injury Epistry database (already the largest available resource of its kind in the world), 2) complete ongoing cardiac arrest and traumatic injury studies in the next 18 months, and 3) implement and complete multiple additional cardiac arrest and traumatic injury clinical trials. The scientifically most premising trauma interventions, targeted for completion during the renewal period include, 1) immediate versus delayed intravenous fluid to decrease hemorrhage and subsequent reperfusion injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and 3) intravenous pentoxifylline to reduce release of inflammatory mediators and reactive oxidants after reperfusion. The scientifically most premising cardiac arrest interventions include: 1) continuous compressions versus standard CPR to improve survival, and 2) implementing therapeutic hypothermia immediately following restoration of circulation to reduce reperfusion injury and improve survival and qualitative outcome. The research design, rationale and techniques for achieving these proposals are specified in the application. Through this 6-year renewal, ROC will leverage its unparalleled infra-structure to significantly reduce morbidity and mortality from cardiac arrest and traumatic injury. Finally, the Toronto site also plans to expand training opportunities by applying for the Clinical Research Development Skills Core.
Cardiovascular disease is the leading cause of death in the United States. Trauma is the leading cause of death among children, adolescents and young adults (ages 1-44) in North America. Improvements in survival and quality of life from continuing the Resuscitation Outcomes Consortium initiative will significantly impact these major national healthcare issues.
|Fink, Ericka L; Prince, David K; Kaltman, Jonathan R et al. (2016) Unchanged pediatric out-of-hospital cardiac arrest incidence and survival rates with regional variation in North America. Resuscitation 107:121-8|
|Kurz, Michael Christopher; Prince, David K; Christenson, James et al. (2016) Association of advanced airway device with chest compression fraction during out-of-hospital cardiopulmonary arrest. Resuscitation 98:35-40|
|Evans, Christopher C D; Petersen, Ashley; Meier, Eric N et al. (2016) Prehospital traumatic cardiac arrest: Management and outcomes from the resuscitation outcomes consortium epistry-trauma and PROPHET registries. J Trauma Acute Care Surg 81:285-93|
|Rizoli, Sandro; Petersen, Ashley; Bulger, Eileen et al. (2016) Early prediction of outcome after severe traumatic brain injury: a simple and practical model. BMC Emerg Med 16:32|
|Morrison, Laurie J; Schmicker, Robert H; Weisfeldt, Myron L et al. (2016) Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium. Resuscitation 100:76-81|
|Salcido, David D; Torres, Cesar; Koller, Allison C et al. (2016) Regional incidence and outcome of out-of-hospital cardiac arrest associated with overdose. Resuscitation 99:13-9|
|Sun, Christopher L F; Demirtas, Derya; Brooks, Steven C et al. (2016) Overcoming Spatial and Temporal BarriersÂ to Public Access Defibrillators ViaÂ Optimization. J Am Coll Cardiol 68:836-45|
|Kudenchuk, Peter J; Brown, Siobhan P; Daya, Mohamud et al. (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. N Engl J Med 374:1711-22|
|Elmer, Jonathan; Torres, Cesar; Aufderheide, Tom P et al. (2016) Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest. Resuscitation 102:127-35|
|Idris, Ahamed H; Guffey, Danielle; Pepe, Paul E et al. (2015) Chest compression rates and survival following out-of-hospital cardiac arrest. Crit Care Med 43:840-8|
Showing the most recent 10 out of 84 publications