The long term objectives of the present studies are to improve the human outcomes from primary cardiac arrest and from serious injury leading to arrest.
The specific aims of this application are: 1) To provide evidence of the University of Alabama at Birmingham's (UAB) ability to participate in multicenter resuscitative clinical trials that will evaluate strategies to improve outcomes from primary cardiac arrest and from traumatic injuries leading to arrest. 2) To document the local network of assembled resources capable of implementing in- and out-of-hospital resuscitation protocols. 3) To demonstrate UAB's ability to develop resuscitation protocols for implementation at the national level. 4) To determine whether responding emergency medical services personnel should perform three minutes of chest compressions prior to defibrillating a person who has been in ventricular fibrillation or pulse-less ventricular tachycardia for five minutes or greater or whether immediate defibrillation results in improved survival to hospital discharge. 5) To determine if the administration of dehydroepiandrosterone (DHEA) to seriously, but non-fatally injured patients during resuscitative efforts administered during the first 120 minutes in the receiving emergency department will result in improved clinical outcomes. 6) To expand UAB's on-going commitment to the training of clinical scientists in the field of resuscitation and emergency medicine through the development of a Clinical Research Skills Development Core and subsequent trainee participation in the Consortium.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL077881-03
Application #
7084484
Study Section
Special Emphasis Panel (ZHL1-CSR-G (M1))
Program Officer
Sopko, George
Project Start
2004-09-01
Project End
2009-04-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
3
Fiscal Year
2006
Total Cost
$585,762
Indirect Cost
Name
University of Alabama Birmingham
Department
Emergency Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Wang, Henry E; Schmicker, Robert H; Daya, Mohamud R et al. (2018) Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA 320:769-778
Pollack, Ross A; Brown, Siobhan P; Rea, Thomas et al. (2018) Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests. Circulation 137:2104-2113
Blewer, Audrey L; McGovern, Shaun K; Schmicker, Robert H et al. (2018) Gender Disparities Among Adult Recipients of Bystander Cardiopulmonary Resuscitation in the Public. Circ Cardiovasc Qual Outcomes 11:e004710
Jones, Allison R; Patel, Rakesh P; Marques, Marisa B et al. (2018) Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial. Ann Emerg Med :
Hansen, Matthew; Schmicker, Robert H; Newgard, Craig D et al. (2018) Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardiac Arrest Among Children and Adults. Circulation 137:2032-2040
Brooks, Steven C; Schmicker, Robert H; Cheskes, Sheldon et al. (2017) Variability in the initiation of resuscitation attempts by emergency medical services personnel during out-of-hospital cardiac arrest. Resuscitation 117:102-108
Salcido, David D; Schmicker, Robert H; Buick, Jason E et al. (2017) Compression-to-ventilation ratio and incidence of rearrest-A secondary analysis of the ROC CCC trial. Resuscitation 115:68-74
Drennan, Ian R; Case, Erin; Verbeek, P Richard et al. (2017) A comparison of the universal TOR Guideline to the absence of prehospital ROSC and duration of resuscitation in predicting futility from out-of-hospital cardiac arrest. Resuscitation 111:96-102
Kudenchuk, Peter J; Leroux, Brian G; Daya, Mohamud et al. (2017) Antiarrhythmic Drugs for Nonshockable-Turned-Shockable Out-of-Hospital Cardiac Arrest: The ALPS Study (Amiodarone, Lidocaine, or Placebo). Circulation 136:2119-2131
Wang, Henry E; Prince, David K; Drennan, Ian R et al. (2017) Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of-hospital cardiac arrest. Resuscitation 120:113-118

Showing the most recent 10 out of 105 publications